Hyaluronan and hyaluronidase in genitourinary tumors

Melanie A. Simpson, Vinata B. Lokeshwar

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Genitourinary cancers are the most frequently diagnosed cancers in men and the fifth most common in women. Management of disease through accurate and cost effective early diagnostic markers, as well as identification of valid prognostic indicators, has contributed significantly to improved treatment outcomes. In this review, we will discuss the function, regulation and clinical utility of hyaluronan (HA), genes encoding its metabolic enzymes and receptors that mediate its cellular effects. Specific HA synthase (HAS) and hyaluronidase (HAase) genes encode the enzymes that produce HA polymers and oligosaccharides, respectively. Differential effects of these enzymes in progression of genitourinary tumors are determined by the relative balance between HAS and HAase levels, as well as the distribution of receptors. The genes are regulated in a complex fashion at the transcriptional and post-translational levels, but also by epigenetic events, alternative mRNA splicing, and subcellular localization. Importantly, the major tumorderived HAase enzyme, HYAL-1, either alone or together with HA, is an accurate diagnostic and prognostic marker for genitourinary tumors.

Original languageEnglish
Pages (from-to)5664-5680
Number of pages17
JournalFrontiers in Bioscience
Volume13
Issue number15
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Hyaluronoglucosaminidase
Hyaluronic Acid
Tumors
Enzymes
Neoplasms
Genes
Urogenital Neoplasms
Gene encoding
Alternative Splicing
Tumor Biomarkers
Disease Management
Oligosaccharides
Epigenomics
Polymers
Costs and Cost Analysis
Messenger RNA
Costs

Keywords

  • Angiogenesis
  • Cancer Diagnosis
  • Cancer Prognosis
  • Hyaluronan
  • Hyaluronic Acid
  • Hyaluronidase
  • Infiltration
  • Review
  • Tumor Growth
  • Tumor Promoter
  • Tumor Suppressor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Hyaluronan and hyaluronidase in genitourinary tumors. / Simpson, Melanie A.; Lokeshwar, Vinata B.

In: Frontiers in Bioscience, Vol. 13, No. 15, 01.05.2008, p. 5664-5680.

Research output: Contribution to journalArticle

Simpson, MA & Lokeshwar, VB 2008, 'Hyaluronan and hyaluronidase in genitourinary tumors', Frontiers in Bioscience, vol. 13, no. 15, pp. 5664-5680. https://doi.org/10.2741/3108
Simpson, Melanie A. ; Lokeshwar, Vinata B. / Hyaluronan and hyaluronidase in genitourinary tumors. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 15. pp. 5664-5680.
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