@article{f90cb44490ee4b81b9feabac18e257c3,
title = "Huntington disease: No evidence for locus heterogeneity",
abstract = "A total of 63 families with Huntington disease (HD) were examined for linkage between HD and G8 (D4S10). The families included 57 Caucasian, four Black American, and two Japanese. The combined maximum lod score was 87.69 at θ = 0.04 (99% confidence interval 0.018-0.071). The maximum frequency of recombination was 0.03 in males and 0.05 in females. Fifty-seven families gave positive lod scores; five small families gave mildly negative lod scores. The maximum likelihood estimate of α, the proportion of linked loci, was 1.0 with a lower 99% confidence interval of 0.88. These data suggest that there is only one HD locus, although a second rare locus cannot be ruled out.",
author = "Conneally, {P. Michael} and Haines, {Jonathan L.} and Tanzi, {Rudolf E.} and Wexler, {Nancy S.} and Penchaszadeh, {Graciela K.} and Harper, {Peter S.} and Folstein, {Susan E.} and Cassiman, {Jean J.} and Myers, {Richard H.} and Young, {Anne B.} and Hayden, {Michael R.} and Arthur Falek and Tolosa, {Eduardo S.} and Sebastian Crespi and {Di Maio}, Luigi and Gosta Holmgren and Maria Anvret and Ichiro Kanazawa and Gusella, {James F.}",
note = "Funding Information: The authors are most grateful to the families who willingly participated in this research. The work was supported by NINCDS Contract NOlNS7-2311, NINCDS Grants lRO1 NS22031 and IROl NS16367, MRC (Canada), and the Hereditary Disease Foundation. Computing time was provided by Indiana University Computing Services.",
year = "1989",
month = aug,
doi = "10.1016/0888-7543(89)90062-1",
language = "English (US)",
volume = "5",
pages = "304--308",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",
}