Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study

Christopher F. McNicoll, Jeanne C. Latourelle, Marcy E. MacDonald, Mark F. Lew, Oksana Suchowersky, Christine Klein, Lawrence I. Golbe, Margery H. Mark, John H. Growdon, G. Frederick Wooten, Ray L. Watts, Mark Guttman, Brad A. Racette, Joel S. Perlmutter, Anwar Ahmed, Holly A. Shill, Carlos Singer, Marie H. Saint-Hilaire, Tiffany Massood, Karen W. HuskeyAnita L. DeStefano, Tammy Gillis, Jayalakshmi Mysore, Stefano Goldwurm, Gianni Pezzoli, Kenneth B. Baker, Ilia Itin, Irene Litvan, Garth Nicholson, Alastair Corbett, Martha Nance, Edward Drasby, Stuart Isaacson, David J. Burn, Patrick F. Chinnery, Peter P. Pramstaller, Jomana Al-Hinti, Anette T. Moller, Karen Ostergaard, Scott J. Sherman, Richard Roxburgh, Barry Snow, John T. Slevin, Franca Cambi, James F. Gusella, Richard H. Myers

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.

Original languageEnglish
Pages (from-to)1596-1601
Number of pages6
JournalMovement Disorders
Volume23
Issue number11
DOIs
StatePublished - Aug 15 2008

Fingerprint

Huntington Disease
Age of Onset
Parkinson Disease
Genes
Adenosine Diphosphate
Adenosine Triphosphate
Alleles
Population

Keywords

  • CAG repeat
  • Genetics
  • Huntington's disease
  • Mitochondria
  • Onset age
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

McNicoll, C. F., Latourelle, J. C., MacDonald, M. E., Lew, M. F., Suchowersky, O., Klein, C., ... Myers, R. H. (2008). Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study. Movement Disorders, 23(11), 1596-1601. https://doi.org/10.1002/mds.22186

Huntington CAG repeat size does not modify onset age in familial Parkinson's disease : The GenePD study. / McNicoll, Christopher F.; Latourelle, Jeanne C.; MacDonald, Marcy E.; Lew, Mark F.; Suchowersky, Oksana; Klein, Christine; Golbe, Lawrence I.; Mark, Margery H.; Growdon, John H.; Wooten, G. Frederick; Watts, Ray L.; Guttman, Mark; Racette, Brad A.; Perlmutter, Joel S.; Ahmed, Anwar; Shill, Holly A.; Singer, Carlos; Saint-Hilaire, Marie H.; Massood, Tiffany; Huskey, Karen W.; DeStefano, Anita L.; Gillis, Tammy; Mysore, Jayalakshmi; Goldwurm, Stefano; Pezzoli, Gianni; Baker, Kenneth B.; Itin, Ilia; Litvan, Irene; Nicholson, Garth; Corbett, Alastair; Nance, Martha; Drasby, Edward; Isaacson, Stuart; Burn, David J.; Chinnery, Patrick F.; Pramstaller, Peter P.; Al-Hinti, Jomana; Moller, Anette T.; Ostergaard, Karen; Sherman, Scott J.; Roxburgh, Richard; Snow, Barry; Slevin, John T.; Cambi, Franca; Gusella, James F.; Myers, Richard H.

In: Movement Disorders, Vol. 23, No. 11, 15.08.2008, p. 1596-1601.

Research output: Contribution to journalArticle

McNicoll, CF, Latourelle, JC, MacDonald, ME, Lew, MF, Suchowersky, O, Klein, C, Golbe, LI, Mark, MH, Growdon, JH, Wooten, GF, Watts, RL, Guttman, M, Racette, BA, Perlmutter, JS, Ahmed, A, Shill, HA, Singer, C, Saint-Hilaire, MH, Massood, T, Huskey, KW, DeStefano, AL, Gillis, T, Mysore, J, Goldwurm, S, Pezzoli, G, Baker, KB, Itin, I, Litvan, I, Nicholson, G, Corbett, A, Nance, M, Drasby, E, Isaacson, S, Burn, DJ, Chinnery, PF, Pramstaller, PP, Al-Hinti, J, Moller, AT, Ostergaard, K, Sherman, SJ, Roxburgh, R, Snow, B, Slevin, JT, Cambi, F, Gusella, JF & Myers, RH 2008, 'Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study', Movement Disorders, vol. 23, no. 11, pp. 1596-1601. https://doi.org/10.1002/mds.22186
McNicoll CF, Latourelle JC, MacDonald ME, Lew MF, Suchowersky O, Klein C et al. Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study. Movement Disorders. 2008 Aug 15;23(11):1596-1601. https://doi.org/10.1002/mds.22186
McNicoll, Christopher F. ; Latourelle, Jeanne C. ; MacDonald, Marcy E. ; Lew, Mark F. ; Suchowersky, Oksana ; Klein, Christine ; Golbe, Lawrence I. ; Mark, Margery H. ; Growdon, John H. ; Wooten, G. Frederick ; Watts, Ray L. ; Guttman, Mark ; Racette, Brad A. ; Perlmutter, Joel S. ; Ahmed, Anwar ; Shill, Holly A. ; Singer, Carlos ; Saint-Hilaire, Marie H. ; Massood, Tiffany ; Huskey, Karen W. ; DeStefano, Anita L. ; Gillis, Tammy ; Mysore, Jayalakshmi ; Goldwurm, Stefano ; Pezzoli, Gianni ; Baker, Kenneth B. ; Itin, Ilia ; Litvan, Irene ; Nicholson, Garth ; Corbett, Alastair ; Nance, Martha ; Drasby, Edward ; Isaacson, Stuart ; Burn, David J. ; Chinnery, Patrick F. ; Pramstaller, Peter P. ; Al-Hinti, Jomana ; Moller, Anette T. ; Ostergaard, Karen ; Sherman, Scott J. ; Roxburgh, Richard ; Snow, Barry ; Slevin, John T. ; Cambi, Franca ; Gusella, James F. ; Myers, Richard H. / Huntington CAG repeat size does not modify onset age in familial Parkinson's disease : The GenePD study. In: Movement Disorders. 2008 ; Vol. 23, No. 11. pp. 1596-1601.
@article{c4689fc75da944fc8cc635232460576c,
title = "Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study",
abstract = "The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2{\%} of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.",
keywords = "CAG repeat, Genetics, Huntington's disease, Mitochondria, Onset age, Parkinson's disease",
author = "McNicoll, {Christopher F.} and Latourelle, {Jeanne C.} and MacDonald, {Marcy E.} and Lew, {Mark F.} and Oksana Suchowersky and Christine Klein and Golbe, {Lawrence I.} and Mark, {Margery H.} and Growdon, {John H.} and Wooten, {G. Frederick} and Watts, {Ray L.} and Mark Guttman and Racette, {Brad A.} and Perlmutter, {Joel S.} and Anwar Ahmed and Shill, {Holly A.} and Carlos Singer and Saint-Hilaire, {Marie H.} and Tiffany Massood and Huskey, {Karen W.} and DeStefano, {Anita L.} and Tammy Gillis and Jayalakshmi Mysore and Stefano Goldwurm and Gianni Pezzoli and Baker, {Kenneth B.} and Ilia Itin and Irene Litvan and Garth Nicholson and Alastair Corbett and Martha Nance and Edward Drasby and Stuart Isaacson and Burn, {David J.} and Chinnery, {Patrick F.} and Pramstaller, {Peter P.} and Jomana Al-Hinti and Moller, {Anette T.} and Karen Ostergaard and Sherman, {Scott J.} and Richard Roxburgh and Barry Snow and Slevin, {John T.} and Franca Cambi and Gusella, {James F.} and Myers, {Richard H.}",
year = "2008",
month = "8",
day = "15",
doi = "10.1002/mds.22186",
language = "English",
volume = "23",
pages = "1596--1601",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

TY - JOUR

T1 - Huntington CAG repeat size does not modify onset age in familial Parkinson's disease

T2 - The GenePD study

AU - McNicoll, Christopher F.

AU - Latourelle, Jeanne C.

AU - MacDonald, Marcy E.

AU - Lew, Mark F.

AU - Suchowersky, Oksana

AU - Klein, Christine

AU - Golbe, Lawrence I.

AU - Mark, Margery H.

AU - Growdon, John H.

AU - Wooten, G. Frederick

AU - Watts, Ray L.

AU - Guttman, Mark

AU - Racette, Brad A.

AU - Perlmutter, Joel S.

AU - Ahmed, Anwar

AU - Shill, Holly A.

AU - Singer, Carlos

AU - Saint-Hilaire, Marie H.

AU - Massood, Tiffany

AU - Huskey, Karen W.

AU - DeStefano, Anita L.

AU - Gillis, Tammy

AU - Mysore, Jayalakshmi

AU - Goldwurm, Stefano

AU - Pezzoli, Gianni

AU - Baker, Kenneth B.

AU - Itin, Ilia

AU - Litvan, Irene

AU - Nicholson, Garth

AU - Corbett, Alastair

AU - Nance, Martha

AU - Drasby, Edward

AU - Isaacson, Stuart

AU - Burn, David J.

AU - Chinnery, Patrick F.

AU - Pramstaller, Peter P.

AU - Al-Hinti, Jomana

AU - Moller, Anette T.

AU - Ostergaard, Karen

AU - Sherman, Scott J.

AU - Roxburgh, Richard

AU - Snow, Barry

AU - Slevin, John T.

AU - Cambi, Franca

AU - Gusella, James F.

AU - Myers, Richard H.

PY - 2008/8/15

Y1 - 2008/8/15

N2 - The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.

AB - The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.

KW - CAG repeat

KW - Genetics

KW - Huntington's disease

KW - Mitochondria

KW - Onset age

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=53149098959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53149098959&partnerID=8YFLogxK

U2 - 10.1002/mds.22186

DO - 10.1002/mds.22186

M3 - Article

C2 - 18649400

AN - SCOPUS:53149098959

VL - 23

SP - 1596

EP - 1601

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 11

ER -