Hunting the genes in male-pattern alopecia

How important are they, how close are we and what will they tell us?

Stefanie Heilmann-Heimbach, Lara M. Hochfeld, Ralf Paus, Markus M. Nöthen

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Androgenetic alopecia (AGA) is a highly heritable condition, and the most common form of hair loss in men. The phenotype is characterized by an androgen-dependent, progressive loss of hair from the scalp, which may commence during puberty. Up to 80% of European men experience some degree of androgen-dependent hair loss during their lifetime. Current treatment options for AGA have limited efficacy, and improved understanding of the underlying biological causes is required to facilitate novel therapeutic approaches. To date, molecular genetic studies have implicated 12 genomic regions in AGA and identified a number of candidate genes. The latter include those encoding the androgen receptor (AR), the histone deacetylases (HDAC) 4 and 9, and the WNT molecule WNT10A. However, the majority of contributing genetic risk factors still await identification. This review describes the current status of AGA genetic research. We discuss the strength of the genetic approach and anticipated developments in the field, and how these will facilitate the systematic unravelling of AGA pathobiology, a process which may lead to the identification of new therapeutic targets.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalExperimental Dermatology
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Alopecia
Genes
Androgens
Histone Deacetylases
Androgen Receptors
Molecules
Genetic Research
Puberty
Scalp
Molecular Biology
Therapeutics
Phenotype

Keywords

  • Androgenetic alopecia
  • Gene identification
  • Hair loss
  • Male-pattern baldness

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Hunting the genes in male-pattern alopecia : How important are they, how close are we and what will they tell us? / Heilmann-Heimbach, Stefanie; Hochfeld, Lara M.; Paus, Ralf; Nöthen, Markus M.

In: Experimental Dermatology, Vol. 25, No. 4, 01.04.2016, p. 251-257.

Research output: Contribution to journalReview article

Heilmann-Heimbach, Stefanie ; Hochfeld, Lara M. ; Paus, Ralf ; Nöthen, Markus M. / Hunting the genes in male-pattern alopecia : How important are they, how close are we and what will they tell us?. In: Experimental Dermatology. 2016 ; Vol. 25, No. 4. pp. 251-257.
@article{2aa8b2b1e6274371ab0c55cc7a5dbb58,
title = "Hunting the genes in male-pattern alopecia: How important are they, how close are we and what will they tell us?",
abstract = "Androgenetic alopecia (AGA) is a highly heritable condition, and the most common form of hair loss in men. The phenotype is characterized by an androgen-dependent, progressive loss of hair from the scalp, which may commence during puberty. Up to 80{\%} of European men experience some degree of androgen-dependent hair loss during their lifetime. Current treatment options for AGA have limited efficacy, and improved understanding of the underlying biological causes is required to facilitate novel therapeutic approaches. To date, molecular genetic studies have implicated 12 genomic regions in AGA and identified a number of candidate genes. The latter include those encoding the androgen receptor (AR), the histone deacetylases (HDAC) 4 and 9, and the WNT molecule WNT10A. However, the majority of contributing genetic risk factors still await identification. This review describes the current status of AGA genetic research. We discuss the strength of the genetic approach and anticipated developments in the field, and how these will facilitate the systematic unravelling of AGA pathobiology, a process which may lead to the identification of new therapeutic targets.",
keywords = "Androgenetic alopecia, Gene identification, Hair loss, Male-pattern baldness",
author = "Stefanie Heilmann-Heimbach and Hochfeld, {Lara M.} and Ralf Paus and N{\"o}then, {Markus M.}",
year = "2016",
month = "4",
day = "1",
doi = "10.1111/exd.12965",
language = "English (US)",
volume = "25",
pages = "251--257",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Hunting the genes in male-pattern alopecia

T2 - How important are they, how close are we and what will they tell us?

AU - Heilmann-Heimbach, Stefanie

AU - Hochfeld, Lara M.

AU - Paus, Ralf

AU - Nöthen, Markus M.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Androgenetic alopecia (AGA) is a highly heritable condition, and the most common form of hair loss in men. The phenotype is characterized by an androgen-dependent, progressive loss of hair from the scalp, which may commence during puberty. Up to 80% of European men experience some degree of androgen-dependent hair loss during their lifetime. Current treatment options for AGA have limited efficacy, and improved understanding of the underlying biological causes is required to facilitate novel therapeutic approaches. To date, molecular genetic studies have implicated 12 genomic regions in AGA and identified a number of candidate genes. The latter include those encoding the androgen receptor (AR), the histone deacetylases (HDAC) 4 and 9, and the WNT molecule WNT10A. However, the majority of contributing genetic risk factors still await identification. This review describes the current status of AGA genetic research. We discuss the strength of the genetic approach and anticipated developments in the field, and how these will facilitate the systematic unravelling of AGA pathobiology, a process which may lead to the identification of new therapeutic targets.

AB - Androgenetic alopecia (AGA) is a highly heritable condition, and the most common form of hair loss in men. The phenotype is characterized by an androgen-dependent, progressive loss of hair from the scalp, which may commence during puberty. Up to 80% of European men experience some degree of androgen-dependent hair loss during their lifetime. Current treatment options for AGA have limited efficacy, and improved understanding of the underlying biological causes is required to facilitate novel therapeutic approaches. To date, molecular genetic studies have implicated 12 genomic regions in AGA and identified a number of candidate genes. The latter include those encoding the androgen receptor (AR), the histone deacetylases (HDAC) 4 and 9, and the WNT molecule WNT10A. However, the majority of contributing genetic risk factors still await identification. This review describes the current status of AGA genetic research. We discuss the strength of the genetic approach and anticipated developments in the field, and how these will facilitate the systematic unravelling of AGA pathobiology, a process which may lead to the identification of new therapeutic targets.

KW - Androgenetic alopecia

KW - Gene identification

KW - Hair loss

KW - Male-pattern baldness

UR - http://www.scopus.com/inward/record.url?scp=84959419770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959419770&partnerID=8YFLogxK

U2 - 10.1111/exd.12965

DO - 10.1111/exd.12965

M3 - Review article

VL - 25

SP - 251

EP - 257

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 4

ER -