Dialysis of cerebral venous blood performed upon rabbits during sleep induced by electrical stimulation of the somnogenic thalamus provided a dialysate which when later injected into a recipient rabbit elicited electrocorticographic manifestations of sleep. Recipients receiving freshly prepared dialysing fluid or dialysate from spontaneously awake, nonstimulated control donors revealed wakeful electrocorticographic patterns. Comparisons of thalamo-cortical and hippocampo-cortical evoked responses in recipients indicated that sleep dialysate enhances the reactivity of the somnogenic thalamic area while simultaneously depressing the excitability of the dorsal hippocampus. Blood pressure, heart rate, respiration rate, and rectal temperature remained stable indicating that cerebral changes induced by sleep dialysate were not secondary concomitants of alterations in these visceral activities. Comparisons between sleep dialysate and other pharmacological substances indicated that its effects generally resembled those of chlorpromazine and substance P, but differed from control dialysate and amphetamine. Fresh sleep dialysate was more potent than dialysate frozen from 10-21 days.
|Original language||English (US)|
|Number of pages||16|
|Journal||Pflügers Archiv für die Gesamte Physiologie des Menschen und der Tiere|
|State||Published - Mar 1 1966|
ASJC Scopus subject areas
- Clinical Biochemistry
- Physiology (medical)