Human viral oncogenesis: A cancer hallmarks analysis

Enrique A. Mesri; Mark A. Feitelson; Karl Munger

doi:10.1016/j.chom.2014.02.011

Human viral oncogenesis: A cancer hallmarks analysis

Enrique A. Mesri, Mark A. Feitelson, Karl Munger

Microbiology & Immunology

Research output: Contribution to journal › Review article

236 Scopus citations

Abstract

Approximately 12% of all human cancers are caused by oncoviruses. Human viral oncogenesis is complex, and only a small percentage of the infected individuals develop cancer, often many years to decades after the initial infection. This reflects the multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribute to only a portion of the oncogenic events. In this review, the Hallmarks of Cancer framework of Hanahan and Weinberg (2000 and 2011) is used to dissect the viral, host, and environmental cofactors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. The viruses discussed include Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), human T cell lymphotropic virus-1 (HTLV-1), and Kaposi's sarcoma herpesvirus (KSHV).

Original language	English (US)
Pages (from-to)	266-282
Number of pages	17
Journal	Cell Host and Microbe
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2014.02.011
State	Published - Mar 12 2014

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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Mesri, E. A., Feitelson, M. A., & Munger, K. (2014). Human viral oncogenesis: A cancer hallmarks analysis. Cell Host and Microbe, 15(3), 266-282. https://doi.org/10.1016/j.chom.2014.02.011

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