Abstract
Approximately 12% of all human cancers are caused by oncoviruses. Human viral oncogenesis is complex, and only a small percentage of the infected individuals develop cancer, often many years to decades after the initial infection. This reflects the multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribute to only a portion of the oncogenic events. In this review, the Hallmarks of Cancer framework of Hanahan and Weinberg (2000 and 2011) is used to dissect the viral, host, and environmental cofactors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. The viruses discussed include Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), human T cell lymphotropic virus-1 (HTLV-1), and Kaposi's sarcoma herpesvirus (KSHV).
| Original language | English |
|---|---|
| Pages (from-to) | 266-282 |
| Number of pages | 17 |
| Journal | Cell Host and Microbe |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 12 2014 |
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ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Cancer Research
- Molecular Biology
Cite this
Human viral oncogenesis : A cancer hallmarks analysis. / Mesri, Enrique A; Feitelson, Mark A.; Munger, Karl.
In: Cell Host and Microbe, Vol. 15, No. 3, 12.03.2014, p. 266-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human viral oncogenesis
T2 - A cancer hallmarks analysis
AU - Mesri, Enrique A
AU - Feitelson, Mark A.
AU - Munger, Karl
PY - 2014/3/12
Y1 - 2014/3/12
N2 - Approximately 12% of all human cancers are caused by oncoviruses. Human viral oncogenesis is complex, and only a small percentage of the infected individuals develop cancer, often many years to decades after the initial infection. This reflects the multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribute to only a portion of the oncogenic events. In this review, the Hallmarks of Cancer framework of Hanahan and Weinberg (2000 and 2011) is used to dissect the viral, host, and environmental cofactors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. The viruses discussed include Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), human T cell lymphotropic virus-1 (HTLV-1), and Kaposi's sarcoma herpesvirus (KSHV).
AB - Approximately 12% of all human cancers are caused by oncoviruses. Human viral oncogenesis is complex, and only a small percentage of the infected individuals develop cancer, often many years to decades after the initial infection. This reflects the multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribute to only a portion of the oncogenic events. In this review, the Hallmarks of Cancer framework of Hanahan and Weinberg (2000 and 2011) is used to dissect the viral, host, and environmental cofactors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. The viruses discussed include Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), human T cell lymphotropic virus-1 (HTLV-1), and Kaposi's sarcoma herpesvirus (KSHV).
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UR - http://www.scopus.com/inward/citedby.url?scp=84896088630&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2014.02.011
DO - 10.1016/j.chom.2014.02.011
M3 - Article
C2 - 24629334
AN - SCOPUS:84896088630
VL - 15
SP - 266
EP - 282
JO - Cell Host and Microbe
JF - Cell Host and Microbe
SN - 1931-3128
IS - 3
ER -