TY - JOUR
T1 - Human viral oncogenesis
T2 - A cancer hallmarks analysis
AU - Mesri, Enrique A.
AU - Feitelson, Mark A.
AU - Munger, Karl
N1 - Funding Information:
We thank Drs. Douglas Hanahan and Robert Weinberg for developing this insightful concept of cancer pathogenesis. It constitutes the inspiration and conceptual framework of this review. We also thank our colleagues for their contributions to our understanding of virally induced cancers. We regret that for space reasons we were not able to comprehensively reference all their contributions. E.A.M. is supported by PHS NIH NCI grants CA 136387, by OHAM/NCI supplements to the Miami CFAR, by the PHS NIAID MIAMI CFAR 5P30AI073961 and by the Bankhead Coley Florida Biomedical Foundation grant 3BB05. M.A.F. is supported by PHS grants CA104025 and AI076535 and by Temple University. K.M. is supported by PHS grants CA081135, CA066980, and CA141583.
PY - 2014/3/12
Y1 - 2014/3/12
N2 - Approximately 12% of all human cancers are caused by oncoviruses. Human viral oncogenesis is complex, and only a small percentage of the infected individuals develop cancer, often many years to decades after the initial infection. This reflects the multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribute to only a portion of the oncogenic events. In this review, the Hallmarks of Cancer framework of Hanahan and Weinberg (2000 and 2011) is used to dissect the viral, host, and environmental cofactors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. The viruses discussed include Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), human T cell lymphotropic virus-1 (HTLV-1), and Kaposi's sarcoma herpesvirus (KSHV).
AB - Approximately 12% of all human cancers are caused by oncoviruses. Human viral oncogenesis is complex, and only a small percentage of the infected individuals develop cancer, often many years to decades after the initial infection. This reflects the multistep nature of viral oncogenesis, host genetic variability, and the fact that viruses contribute to only a portion of the oncogenic events. In this review, the Hallmarks of Cancer framework of Hanahan and Weinberg (2000 and 2011) is used to dissect the viral, host, and environmental cofactors that contribute to the biology of multistep oncogenesis mediated by established human oncoviruses. The viruses discussed include Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), human T cell lymphotropic virus-1 (HTLV-1), and Kaposi's sarcoma herpesvirus (KSHV).
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U2 - 10.1016/j.chom.2014.02.011
DO - 10.1016/j.chom.2014.02.011
M3 - Review article
C2 - 24629334
AN - SCOPUS:84896088630
VL - 15
SP - 266
EP - 282
JO - Cell Host and Microbe
JF - Cell Host and Microbe
SN - 1931-3128
IS - 3
ER -