Human tissue distribution of platinum after cis-diamminedichloroplatinum

David J. Stewart, Robert S. Benjamin, Mario Luna, Lynn G Feun, Richard Caprioli, William Seifert, Ti Li Loo

Research output: Contribution to journalArticle

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Abstract

Using X-ray fluorescence spectrometry, platinum concentrations were determined in autopsy tissue samples from 12 patients who had received cis-diamminedichloroplatinum (DDP) 20-120 mg/m2 up to 6 months antemortem. Tissue platinum concentrations were highest in liver (0.5-3.7 μg/g wet weight), prostate (1.6-3.6 μg/g), and kidney (0.4-2.9 μg/g), somewhat lower in bladder, muscle, testicle, pancreas, and spleen, and lowest in bowel, adrenal, heart, lung, cerebrum, and cerebellum, Platinum concentrations in tumors were generally somewhat lower than the concentration in the organ in which the tumor was located, with the exception of intracerebral tumors. Different metastatic sites in the same patient had substantially different platinum concentrations and hepatic metasutases had the highest concentrations. Intra-arterial administration of drug may augment tissue concentrations of platinum. In a patient undergoing therapeutic abortion 4 days after treatment, the platinum concentration was 0.5 μg/g in the placenta and 0.3 μg/g in the fetus. The data suggest that for in vitro sensitivity testing, DDP concentrations of ≦7 μg/ml should be used.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalCancer Chemotherapy and Pharmacology
Volume10
Issue number1
DOIs
StatePublished - Dec 1 1982
Externally publishedYes

Fingerprint

Tissue Distribution
Platinum
Cisplatin
Tissue
Tumors
X-Ray Emission Spectrometry
Therapeutic Abortion
Neoplasms
Liver
Cerebrum
Cerebellum
Placenta
Muscle
Testis
Prostate
Pancreas
Autopsy
Urinary Bladder
Fetus
Spleen

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

Cite this

Stewart, D. J., Benjamin, R. S., Luna, M., Feun, L. G., Caprioli, R., Seifert, W., & Loo, T. L. (1982). Human tissue distribution of platinum after cis-diamminedichloroplatinum. Cancer Chemotherapy and Pharmacology, 10(1), 51-54. https://doi.org/10.1007/BF00257239

Human tissue distribution of platinum after cis-diamminedichloroplatinum. / Stewart, David J.; Benjamin, Robert S.; Luna, Mario; Feun, Lynn G; Caprioli, Richard; Seifert, William; Loo, Ti Li.

In: Cancer Chemotherapy and Pharmacology, Vol. 10, No. 1, 01.12.1982, p. 51-54.

Research output: Contribution to journalArticle

Stewart, DJ, Benjamin, RS, Luna, M, Feun, LG, Caprioli, R, Seifert, W & Loo, TL 1982, 'Human tissue distribution of platinum after cis-diamminedichloroplatinum', Cancer Chemotherapy and Pharmacology, vol. 10, no. 1, pp. 51-54. https://doi.org/10.1007/BF00257239
Stewart, David J. ; Benjamin, Robert S. ; Luna, Mario ; Feun, Lynn G ; Caprioli, Richard ; Seifert, William ; Loo, Ti Li. / Human tissue distribution of platinum after cis-diamminedichloroplatinum. In: Cancer Chemotherapy and Pharmacology. 1982 ; Vol. 10, No. 1. pp. 51-54.
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