Human T-lymphotropic virus type i or II (HTLV-I/II) associated with recurrent longitudinally extensive transverse myelitis (LETM): Two case reports

Silvia R. Delgado, William A. Sheremata, Andrew D. Brown, Micheline McCarthy

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We describe two patients with recurrent longitudinally extensive transverse myelitis (LETM) associated with human T-lymphotropic virus type I or II (HTLV-I/II) exposure, and with neuromyelitis optica (NMO) immunoglobulin G (IgG) antibody in one case. HTLV-I/II are well known retroviral agents of myelopathy and B-cell dysfunction in humans. NMO is an autoimmune, demyelinating disorder of the central nervous system (CNS), also linked to B-cell dysfunction. Therefore, the immunopathogenesis of NMO may in some cases be linked to human HTLV exposure. Awareness of a possible association with human retroviral exposure will contribute to the optimal diagnosis and management of patients presenting with LETM or NMO.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalJournal of neurovirology
Volume16
Issue number3
DOIs
StatePublished - Jun 1 2010

Keywords

  • CNS demyelinating diseases
  • Devic's disease
  • HTLV-I/II
  • Longitudinally extensive transverse myelitis
  • Myelopathy
  • Neuromyelitis optica
  • NMO

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

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