Abstract
The human T-cell lymphotropic viruses type I and type II are closely related human retroviruses that have similar biological properties, genetic organization and tropism for T lymphocytes. Along with the simian T-cell lymphoma virus type I, they define the group of retroviruses known as the primate T-cell leukemia/lymphoma viruses. Initially identified in 1980, the human T-cell lymphotropic virus type I has been implicated as the etiologic agent of adult T-cell leukemia/lymphoma and of a degenerative neurologic disorder known as tropical spastic paraparesis or human T-cell lymphotropic virus type I-associated myelopathy. The intriguing link between human T-cell lymphotropic virus type, T-cell malignancy, and a totally unrelated and non-overlapping neurological disorder suggests divergent and unique pathogenetic mechanisms. This review will address the epidemiology, molecular biology, and pathogenesis of human T-cell leukemia viruses.
| Original language | English |
|---|---|
| Pages (from-to) | 91-104 |
| Number of pages | 14 |
| Journal | Blood Reviews |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Human T-cell leukemia viruses : Epidemiology, biology, and pathogenesis. / Ferreira, O. C.; Planelles, V.; Rosenblatt, Joseph D.
In: Blood Reviews, Vol. 11, No. 2, 01.06.1997, p. 91-104.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human T-cell leukemia viruses
T2 - Epidemiology, biology, and pathogenesis
AU - Ferreira, O. C.
AU - Planelles, V.
AU - Rosenblatt, Joseph D
PY - 1997/6/1
Y1 - 1997/6/1
N2 - The human T-cell lymphotropic viruses type I and type II are closely related human retroviruses that have similar biological properties, genetic organization and tropism for T lymphocytes. Along with the simian T-cell lymphoma virus type I, they define the group of retroviruses known as the primate T-cell leukemia/lymphoma viruses. Initially identified in 1980, the human T-cell lymphotropic virus type I has been implicated as the etiologic agent of adult T-cell leukemia/lymphoma and of a degenerative neurologic disorder known as tropical spastic paraparesis or human T-cell lymphotropic virus type I-associated myelopathy. The intriguing link between human T-cell lymphotropic virus type, T-cell malignancy, and a totally unrelated and non-overlapping neurological disorder suggests divergent and unique pathogenetic mechanisms. This review will address the epidemiology, molecular biology, and pathogenesis of human T-cell leukemia viruses.
AB - The human T-cell lymphotropic viruses type I and type II are closely related human retroviruses that have similar biological properties, genetic organization and tropism for T lymphocytes. Along with the simian T-cell lymphoma virus type I, they define the group of retroviruses known as the primate T-cell leukemia/lymphoma viruses. Initially identified in 1980, the human T-cell lymphotropic virus type I has been implicated as the etiologic agent of adult T-cell leukemia/lymphoma and of a degenerative neurologic disorder known as tropical spastic paraparesis or human T-cell lymphotropic virus type I-associated myelopathy. The intriguing link between human T-cell lymphotropic virus type, T-cell malignancy, and a totally unrelated and non-overlapping neurological disorder suggests divergent and unique pathogenetic mechanisms. This review will address the epidemiology, molecular biology, and pathogenesis of human T-cell leukemia viruses.
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UR - http://www.scopus.com/inward/citedby.url?scp=12644304238&partnerID=8YFLogxK
U2 - 10.1016/S0268-960X(97)90015-1
DO - 10.1016/S0268-960X(97)90015-1
M3 - Article
C2 - 9242992
AN - SCOPUS:12644304238
VL - 11
SP - 91
EP - 104
JO - Blood Reviews
JF - Blood Reviews
SN - 0268-960X
IS - 2
ER -