Abstract
Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin-mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti-protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing.
| Original language | English |
|---|---|
| Pages (from-to) | 367-370 |
| Number of pages | 4 |
| Journal | Journal of Experimental Medicine |
| Volume | 172 |
| Issue number | 1 |
| State | Published - Jul 1 1990 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis. / Meri, Seppo; Morgan, B. Paul; Wing, Mark; Jones, Jane; Davies, Alexandra; Podack, Eckhard; Lachmann, Peter J.
In: Journal of Experimental Medicine, Vol. 172, No. 1, 01.07.1990, p. 367-370.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis
AU - Meri, Seppo
AU - Morgan, B. Paul
AU - Wing, Mark
AU - Jones, Jane
AU - Davies, Alexandra
AU - Podack, Eckhard
AU - Lachmann, Peter J.
PY - 1990/7/1
Y1 - 1990/7/1
N2 - Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin-mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti-protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing.
AB - Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin-mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti-protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing.
UR - http://www.scopus.com/inward/record.url?scp=0025368397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025368397&partnerID=8YFLogxK
M3 - Article
C2 - 1694224
AN - SCOPUS:0025368397
VL - 172
SP - 367
EP - 370
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 1
ER -