Human protectin (CD59), an 18-20-kD homologous complement restriction factor, does not restrict perforin-mediated lysis

Seppo Meri, B. Paul Morgan, Mark Wing, Jane Jones, Alexandra Davies, Eckhard Podack, Peter J. Lachmann

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Human protectin (CD59) is an 18-20-kD membrane glycoprotein that restricts lysis of human erythrocytes and leukocytes by homologous complement. By directly incorporating protectin into membranes of heterologous cells we observed that protectin did not prevent perforin-mediated killing, whereas complement killing was effectively restricted. Further, no significant enhancement of cell-mediated killing or target killing by purified perforin was observed with anti-protectin antibodies. Thus, in contrast with complement lysis, restriction of lysis by protectin does not apply to cell-mediated killing.

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalJournal of Experimental Medicine
Volume172
Issue number1
DOIs
StatePublished - Jul 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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