Human peripheral blood and splenic T lymphocyte reactions versus kidney cortical cells

D. Roth, G. K. Kyriakides, L. Fuller, J. Miller

Research output: Contribution to journalArticle

Abstract

These data suggest that a lymphoproliferative response to kidney-specific antigens might have been unmasked or amplified by the enzymatic digestion (collagenase, neuraminidase) used in deriving the KC cell population, a reaction not dependent on Ia antigens (at least as defined by L243 anti-DR antibody) as in the allogeneic response. The MLKC data obtained using infiltrating lymphocytes isolated from ESRD kidneys provokes questions regarding the contribution of T cell-mediated autoimmunity in the progression to chronic renal failure.

Original languageEnglish (US)
Pages (from-to)1532-1534
Number of pages3
JournalTransplantation proceedings
Volume16
Issue number6
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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