Human neural tube defects: Developmental biology, epidemiology, and genetics

Eric R. Detrait, Timothy M. George, Heather C. Etchevers, John Gilbert, Michel Vekemans, Marcy C. Speer

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

Birth defects (congenital anomalies) are the leading cause of death in babies under 1 year of age. Neural tube defects (NTD), with a birth incidence of approximately 1/1000 in American Caucasians, are the second most common type of birth defect after congenital heart defects. The most common presentations of NTD are spina bifida and anencephaly. The etiologies of NTDs are complex, with both genetic and environmental factors implicated. In this manuscript, we review the evidence for genetic etiology and for environmental influences, and we present current views on the developmental processes involved in human neural tube closure.

Original languageEnglish
Pages (from-to)515-524
Number of pages10
JournalNeurotoxicology and Teratology
Volume27
Issue number3
DOIs
StatePublished - May 1 2005
Externally publishedYes

Fingerprint

Developmental Biology
Epidemiology
Molecular Epidemiology
Neural Tube Defects
Defects
Neural Tube
Congenital Heart Defects
Cause of Death
Parturition
Incidence
Genetics
Neural tube defects X-linked

Keywords

  • Genetics
  • Neural tube defect
  • Teratology

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Detrait, E. R., George, T. M., Etchevers, H. C., Gilbert, J., Vekemans, M., & Speer, M. C. (2005). Human neural tube defects: Developmental biology, epidemiology, and genetics. Neurotoxicology and Teratology, 27(3), 515-524. https://doi.org/10.1016/j.ntt.2004.12.007

Human neural tube defects : Developmental biology, epidemiology, and genetics. / Detrait, Eric R.; George, Timothy M.; Etchevers, Heather C.; Gilbert, John; Vekemans, Michel; Speer, Marcy C.

In: Neurotoxicology and Teratology, Vol. 27, No. 3, 01.05.2005, p. 515-524.

Research output: Contribution to journalArticle

Detrait, ER, George, TM, Etchevers, HC, Gilbert, J, Vekemans, M & Speer, MC 2005, 'Human neural tube defects: Developmental biology, epidemiology, and genetics', Neurotoxicology and Teratology, vol. 27, no. 3, pp. 515-524. https://doi.org/10.1016/j.ntt.2004.12.007
Detrait ER, George TM, Etchevers HC, Gilbert J, Vekemans M, Speer MC. Human neural tube defects: Developmental biology, epidemiology, and genetics. Neurotoxicology and Teratology. 2005 May 1;27(3):515-524. https://doi.org/10.1016/j.ntt.2004.12.007
Detrait, Eric R. ; George, Timothy M. ; Etchevers, Heather C. ; Gilbert, John ; Vekemans, Michel ; Speer, Marcy C. / Human neural tube defects : Developmental biology, epidemiology, and genetics. In: Neurotoxicology and Teratology. 2005 ; Vol. 27, No. 3. pp. 515-524.
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