TY - JOUR
T1 - Human islet transplantation
T2 - Update
AU - Boker, Andres
AU - Rothenberg, Lisa
AU - Hernandez, Claudia
AU - Kenyon, Norma S.
AU - Ricordi, Camillo
AU - Alejandro, Rodolfo
PY - 2001/4
Y1 - 2001/4
N2 - New hope for the treatment of type 1 diabetes has recently emerged from the encouraging results of islet cell transplantation in humans during the last few years. Although still facing considerable problems, the challenge to achieving insulin independence has been overcome in some patients who received an islet graft. However; the success of clinical trials is still limited by the inability to transplant enough viable human islets to compensate for the insulin-deficient state, the number of islets that engraft following transplantation, the rejection process, and the recurrence of autoimmunity. The important advances in immunosuppressive regimens, organ procurement techniques, isolation techniques, and availability of defined collagenase blends have contributed to the continuing promise of making islet cell transplantation the treatment of choice for type 1 diabetes mellitus.
AB - New hope for the treatment of type 1 diabetes has recently emerged from the encouraging results of islet cell transplantation in humans during the last few years. Although still facing considerable problems, the challenge to achieving insulin independence has been overcome in some patients who received an islet graft. However; the success of clinical trials is still limited by the inability to transplant enough viable human islets to compensate for the insulin-deficient state, the number of islets that engraft following transplantation, the rejection process, and the recurrence of autoimmunity. The important advances in immunosuppressive regimens, organ procurement techniques, isolation techniques, and availability of defined collagenase blends have contributed to the continuing promise of making islet cell transplantation the treatment of choice for type 1 diabetes mellitus.
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U2 - 10.1007/s002680020341
DO - 10.1007/s002680020341
M3 - Review article
C2 - 11344402
AN - SCOPUS:0035016543
VL - 25
SP - 481
EP - 486
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 4
ER -