Human Immunodeficiency Viruses: Pathogenesis

Nichole Klatt, A. Chahroudi, G. Silvestri

Research output: Chapter in Book/Report/Conference proceedingChapter


Despite many years of intense research effort, the pathogenesis of HIV infection and AIDS is still poorly understood. Particularly, it is unclear to what extent the progressive immunodeficiency that follows HIV infection is caused by direct, virus-mediated killing of infected CD4+ T cells as opposed to the indirect consequences of the chronic immune system activation. Important advances in our understanding of HIV/AIDS pathogenesis came from a series of recent studies focusing on: (1) the immunological events characteristic of the acute and chronic phases of infection; (2) the impact of HIV infection at the level of mucosa associated lymphoid tissues; and (3) the specific features of natural, nonpathogenic SIV infection of African nonhuman primates. Collectively, these studies have defined a model for the immunopathogenesis of primate lentiviral infections that is more complex than previously appreciated and that highlights the key role played by host-related, species-specific factors. Ultimately, it is hoped that these advances will provide information that will be useful to the design of interventions able to successfully prevent and/or eradicate HIV infection in humans.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Virology
PublisherElsevier Ltd
Number of pages9
ISBN (Print)9780123744104
StatePublished - Jan 1 2008
Externally publishedYes


  • AIDS
  • CD4+ T-lymphocyte
  • Cytotoxic T-lymphocyte
  • Dendritic cell
  • HIV
  • Immune activation
  • Immune evasion
  • Mucosal-associated lymphoid tissue
  • Natural host
  • Neutralizing antibody
  • SIV
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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