Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients

Elena E. Perez, Stephanie L. Rose, Brian Peyser, Susanna L. Lamers, Brant Burkhardt, Ben M. Dunn, Alan D. Hutson, John W. Sleasman, Maureen M. Goodenow

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Protease genotype, as a variable in outcome to combination therapy for human immuno-deficiency virus (HIV) type 1 infection, was evaluated among protease inhibitor-naive children and adolescents who had received extensive treatment with reverse-transcriptase inhibitors. After 24 weeks of combination therapy, 35% had viral and immune success (VSIS patients), 19% had viral and immune failure (VFIF patients), and 46% had viral failure but marked improvement in CD4 T cells (VFIS patients). Disease stage was the only pretherapy clinical variable associated with outcome (P = .02). Although reverse-transcriptase genotype was unrelated to outcome, pretherapy protease genotype was related significantly to therapy response (P =.005). Odds for immune or viral failure were 17.7 to 1 and 2.5 to 1, respectively, for protease genotype as a single variable. Protease genotype combined with disease stage and CD4 cell percentage predicted correct therapy response for 81% of patients (100% of VFIF, 78% of VSIS, and 75% of VFIS patiens). Naturally occurring amino acid polymorphisms in protease provide sensitive biomarkers for treatment response among inhibitor-naive patients with advanced HIV disease.

Original languageEnglish (US)
Pages (from-to)579-588
Number of pages10
JournalJournal of Infectious Diseases
Volume183
Issue number4
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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