Abstract
Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.
| Original language | English |
|---|---|
| Pages (from-to) | 648-655 |
| Number of pages | 8 |
| Journal | Journal of Infectious Diseases |
| Volume | 172 |
| Issue number | 3 |
| State | Published - Jan 1 1995 |
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ASJC Scopus subject areas
- Immunology
- Public Health, Environmental and Occupational Health
Cite this
Human immunodeficiency virus type 1 infection : Relationship of risk group and age to rate of progression to AIDS. / Operskalski, E. A.; Stram, D. O.; Lee, H.; Zhou, Y.; Donegan, E.; Busch, M. P.; Stevens, C. E.; Schiff, Eugene R; Dietrich, S. L.; Mosley, J. W.; Nowicki, M. J.; Pike, M. C.; Stram, D.; Zhou, Y.; Kleinman, S. H.; Lusher, J. M.; Schiff, E. R.; Harris, M.; Kasper, C. K.
In: Journal of Infectious Diseases, Vol. 172, No. 3, 01.01.1995, p. 648-655.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human immunodeficiency virus type 1 infection
T2 - Relationship of risk group and age to rate of progression to AIDS
AU - Operskalski, E. A.
AU - Stram, D. O.
AU - Lee, H.
AU - Zhou, Y.
AU - Donegan, E.
AU - Busch, M. P.
AU - Stevens, C. E.
AU - Schiff, Eugene R
AU - Dietrich, S. L.
AU - Mosley, J. W.
AU - Nowicki, M. J.
AU - Pike, M. C.
AU - Stram, D.
AU - Zhou, Y.
AU - Kleinman, S. H.
AU - Lusher, J. M.
AU - Schiff, E. R.
AU - Harris, M.
AU - Kasper, C. K.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.
AB - Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.
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M3 - Article
C2 - 7658055
AN - SCOPUS:0029135361
VL - 172
SP - 648
EP - 655
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -