TY - JOUR
T1 - Human immunodeficiency virus type 1 infection
T2 - relationship of risk group and age to rate of progression to aids
AU - Centers for Disease Control
AU - Operskalski, Eva A.
AU - Stram, Daniel O.
AU - Lee, Hang
AU - Zhou, Yi
AU - Donegan, Elizabeth
AU - Busch, Michael P.
AU - Stevens, Cladd E.
AU - Schiff, Eugene R.
AU - Dietrich, Shelby L.
AU - Mosley, James W.
N1 - Funding Information:
Received 30 January 1995; revised I May 1995. Presented in part: VII International Conference on AIDS, June 1991, Florence, Italy (abstract TU.C.50). Informed consent was obtained from patients or their parents or guardians (including that specifically for HIV testing). Human experimentation guidelines of the US Department of Health and Human Services and those of the authors' institutions were followed in the conduct of the clinical research. Contract support: National Institutes of Health (HB-4-7002, 4-7003, and 9-7074). Reprints or correspondence: Dr. James W. Mosley, Transfusion Safety Study, University of Southern California School of Medicine, 1840 N. Soto St. (EDM 108), Los Angeles, CA 90032. * Other participating institutions and personnel are listed in Acknowledgments.
PY - 1995/9
Y1 - 1995/9
N2 - Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.
AB - Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.
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U2 - 10.1093/infdis/172.3.648
DO - 10.1093/infdis/172.3.648
M3 - Article
C2 - 7658055
AN - SCOPUS:0029135361
VL - 172
SP - 648
EP - 655
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -