Human immunodeficiency virus type 1 infection: Relationship of risk group and age to rate of progression to AIDS

E. A. Operskalski, D. O. Stram, H. Lee, Y. Zhou, E. Donegan, M. P. Busch, C. E. Stevens, Eugene R Schiff, S. L. Dietrich, J. W. Mosley, M. J. Nowicki, M. C. Pike, D. Stram, Y. Zhou, S. H. Kleinman, J. M. Lusher, E. R. Schiff, M. Harris, C. K. Kasper

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.

Original languageEnglish
Pages (from-to)648-655
Number of pages8
JournalJournal of Infectious Diseases
Volume172
Issue number3
StatePublished - Jan 1 1995

Fingerprint

Virus Diseases
HIV-1
Acquired Immunodeficiency Syndrome
Age Groups
Tissue Donors
Zidovudine
Kaposi's Sarcoma
Factor VIII
CD4 Lymphocyte Count
Blood Donors
Infection
Sexual Minorities
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Operskalski, E. A., Stram, D. O., Lee, H., Zhou, Y., Donegan, E., Busch, M. P., ... Kasper, C. K. (1995). Human immunodeficiency virus type 1 infection: Relationship of risk group and age to rate of progression to AIDS. Journal of Infectious Diseases, 172(3), 648-655.

Human immunodeficiency virus type 1 infection : Relationship of risk group and age to rate of progression to AIDS. / Operskalski, E. A.; Stram, D. O.; Lee, H.; Zhou, Y.; Donegan, E.; Busch, M. P.; Stevens, C. E.; Schiff, Eugene R; Dietrich, S. L.; Mosley, J. W.; Nowicki, M. J.; Pike, M. C.; Stram, D.; Zhou, Y.; Kleinman, S. H.; Lusher, J. M.; Schiff, E. R.; Harris, M.; Kasper, C. K.

In: Journal of Infectious Diseases, Vol. 172, No. 3, 01.01.1995, p. 648-655.

Research output: Contribution to journalArticle

Operskalski, EA, Stram, DO, Lee, H, Zhou, Y, Donegan, E, Busch, MP, Stevens, CE, Schiff, ER, Dietrich, SL, Mosley, JW, Nowicki, MJ, Pike, MC, Stram, D, Zhou, Y, Kleinman, SH, Lusher, JM, Schiff, ER, Harris, M & Kasper, CK 1995, 'Human immunodeficiency virus type 1 infection: Relationship of risk group and age to rate of progression to AIDS', Journal of Infectious Diseases, vol. 172, no. 3, pp. 648-655.
Operskalski EA, Stram DO, Lee H, Zhou Y, Donegan E, Busch MP et al. Human immunodeficiency virus type 1 infection: Relationship of risk group and age to rate of progression to AIDS. Journal of Infectious Diseases. 1995 Jan 1;172(3):648-655.
Operskalski, E. A. ; Stram, D. O. ; Lee, H. ; Zhou, Y. ; Donegan, E. ; Busch, M. P. ; Stevens, C. E. ; Schiff, Eugene R ; Dietrich, S. L. ; Mosley, J. W. ; Nowicki, M. J. ; Pike, M. C. ; Stram, D. ; Zhou, Y. ; Kleinman, S. H. ; Lusher, J. M. ; Schiff, E. R. ; Harris, M. ; Kasper, C. K. / Human immunodeficiency virus type 1 infection : Relationship of risk group and age to rate of progression to AIDS. In: Journal of Infectious Diseases. 1995 ; Vol. 172, No. 3. pp. 648-655.
@article{d1af53d624894d80a5ef17ca8029e2ec,
title = "Human immunodeficiency virus type 1 infection: Relationship of risk group and age to rate of progression to AIDS",
abstract = "Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51{\%} among blood recipients, 36{\%} among homosexual donors, and 24{\%} among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.",
author = "Operskalski, {E. A.} and Stram, {D. O.} and H. Lee and Y. Zhou and E. Donegan and Busch, {M. P.} and Stevens, {C. E.} and Schiff, {Eugene R} and Dietrich, {S. L.} and Mosley, {J. W.} and Nowicki, {M. J.} and Pike, {M. C.} and D. Stram and Y. Zhou and Kleinman, {S. H.} and Lusher, {J. M.} and Schiff, {E. R.} and M. Harris and Kasper, {C. K.}",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "172",
pages = "648--655",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Human immunodeficiency virus type 1 infection

T2 - Relationship of risk group and age to rate of progression to AIDS

AU - Operskalski, E. A.

AU - Stram, D. O.

AU - Lee, H.

AU - Zhou, Y.

AU - Donegan, E.

AU - Busch, M. P.

AU - Stevens, C. E.

AU - Schiff, Eugene R

AU - Dietrich, S. L.

AU - Mosley, J. W.

AU - Nowicki, M. J.

AU - Pike, M. C.

AU - Stram, D.

AU - Zhou, Y.

AU - Kleinman, S. H.

AU - Lusher, J. M.

AU - Schiff, E. R.

AU - Harris, M.

AU - Kasper, C. K.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.

AB - Age differences among risk groups may account for rate differences in progression of human immunodeficiency virus type 1 (HIV-1) infection to AIDS. Institutions in 6 US cities used a common protocol to study infected homosexual blood donors, recipients of blood components, and factor VIII- treated hemophiliacs. Follow-up was every 6 months. Actuarial risk for AIDS 8 years after infection was 51% among blood recipients, 36% among homosexual donors, and 24% among hemophiliacs. Significant risk group differences were explained by age differences among cohorts (medians of 61, 29, and 22 years, respectively). When age was adjusted for and both CD4 cell value and zidovudine treatment were used as time-dependent covariates, homosexual donors had more rapid progression than the other groups. Omitting Kaposi's sarcoma as an AIDS-defining condition removed any significant differences among risk groups except CD4 cell count and age. Thus, major factors in AIDS progression are age-related.

UR - http://www.scopus.com/inward/record.url?scp=0029135361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029135361&partnerID=8YFLogxK

M3 - Article

C2 - 7658055

AN - SCOPUS:0029135361

VL - 172

SP - 648

EP - 655

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -