Human immunodeficiency virus type 1 compartmentalization in the central nervous system

Carol Petito

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

HIV-1 replicates in monocyte-derived cells in multiple organ systems; in the central nervous system, productive infection is confined to monocyte lineage cells in the brain. In addition, productive viral infection takes place in the choroid plexus, where the incidence of infection is actually higher than in brain and is present prior to the onset of AIDS and immunosuppression. Restricted or latent infection occurs in astrocytes and neurons. The presence of perineuronal CD4+ lymphocytes, as well as activated microglia, support the potential for a trans-receptor mechanism of viral entry whereas intrinsic gene profiles do not appear to participate in conferring selective neuronal vulnerability or resistance to infection.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalJournal of NeuroVirology
Volume10
Issue numberSUPPL. 1
StatePublished - Mar 22 2004

Fingerprint

HIV-1
Central Nervous System
Infection
Monocytes
Choroid Plexus
Brain
Microglia
Virus Diseases
Astrocytes
Immunosuppression
Acquired Immunodeficiency Syndrome
Lymphocytes
Neurons
Incidence
Genes

Keywords

  • Chemokine receptors
  • Choroid plexus
  • Microarrays
  • Neurons
  • T lymphocytes

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Human immunodeficiency virus type 1 compartmentalization in the central nervous system. / Petito, Carol.

In: Journal of NeuroVirology, Vol. 10, No. SUPPL. 1, 22.03.2004, p. 21-24.

Research output: Contribution to journalArticle

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