Human immunodeficiency virus type 1 compartmentalization in the central nervous system

Carol K. Petito

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

HIV-1 replicates in monocyte-derived cells in multiple organ systems; in the central nervous system, productive infection is confined to monocyte lineage cells in the brain. In addition, productive viral infection takes place in the choroid plexus, where the incidence of infection is actually higher than in brain and is present prior to the onset of AIDS and immunosuppression. Restricted or latent infection occurs in astrocytes and neurons. The presence of perineuronal CD4+ lymphocytes, as well as activated microglia, support the potential for a trans-receptor mechanism of viral entry whereas intrinsic gene profiles do not appear to participate in conferring selective neuronal vulnerability or resistance to infection.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalJournal of neurovirology
Volume10
Issue numberSUPPL. 1
DOIs
StatePublished - 2004

Keywords

  • Chemokine receptors
  • Choroid plexus
  • Microarrays
  • Neurons
  • T lymphocytes

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Human immunodeficiency virus type 1 compartmentalization in the central nervous system'. Together they form a unique fingerprint.

  • Cite this