Human immunodeficiency virus cultured from bone. Implications for transplantation

B. E. Buck, L. Resnick, S. M. Shah, T. I. Malinin

Research output: Contribution to journalArticlepeer-review

220 Scopus citations


This study demonstrates by a virologic culture method that human immunodeficiency virus (HIV) resides in bone. After freezing, some initially positive specimens no longer yielded virus, but those that continued to yield virus were not further altered by subsequent washing, which removed essentially all marrow, or by freeze-drying. The safeguards against potential transmission of HIV by a bone allograft are principally the screening and testing methods previously described, although there may be a further reduction of the remote residual risk by the freezing step in the usual technical sequence for tissue banking by sterile techniques.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalClinical orthopaedics and related research
Issue number251
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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