Human Immunodeficiency Virus and Human T-Cell Leukemia Virus Type I in Patients Undergoing Maintenance Hemodialysis in Miami

Guido Perez, Carmen Ortiz-Interian, Helen Lee, Maria de Medina, Michael Cerney, Jean Pierre Allain, Eugene Schiff, Elizabeth Parks, Wade Parks, Jacques J. Bourgoignie

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The high prevalence of human immunodeficiency virus (HIV-1) infection in populations at risk in Miami prompted a seroepidemiologic study of both HIV-1 and the human T-cell leukemia virus type I (HTLV-I), a closely related virus, in our patients receiving chronic hemodialysis. One hundred twenty-nine patients undergoing hemodialysis in 1986 and 1987 were tested for antibody against both viral antigens by EIA (Abbott Laboratories, Abbott Park, IL). Seroreactive samples for HIV-1 and HTLV-I were confirmed by Western blot and, for HTLV-I, by viral cultures. Thirty patients (23.2%) were positive for retroviral infection (22 for HIV-1 alone, four for HTLV-I alone, and four for both HIV-1 and HTLV-I). The most important risk factor was intravenous drug use, followed by blood transfusion. Patients with HIV-1 had lower T4-T8 ratios and higher mortality than those with HTLV-I infection alone. It was concluded that HTLV-I, as well as HIV-1, infection is endemic in chronic dialysis centers in Miami. The clinical consequences of HTLV-I infection in relatively immunocompromised patients with chronic uremia who are undergoing chronic hemodialysis remains to be established.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume14
Issue number1
DOIs
StatePublished - Jan 1 1989

Keywords

  • HIV-1
  • HTLV-I
  • chronic hemodialysis

ASJC Scopus subject areas

  • Nephrology

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    Perez, G., Ortiz-Interian, C., Lee, H., de Medina, M., Cerney, M., Allain, J. P., Schiff, E., Parks, E., Parks, W., & Bourgoignie, J. J. (1989). Human Immunodeficiency Virus and Human T-Cell Leukemia Virus Type I in Patients Undergoing Maintenance Hemodialysis in Miami. American Journal of Kidney Diseases, 14(1), 39-43. https://doi.org/10.1016/S0272-6386(89)80091-5