Human immunodeficiency virus and human T-cell leukemia virus type I in patients undergoing maintenance hemodialysis in Miami

G. Perez, C. Ortiz-Interian, H. Lee, M. De Medina, M. Cerney, J. P. Allain, Eugene R Schiff, E. Parks, W. Parks, J. J. Bourgoignie

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Abstract

The high prevalence of human immunodeficiency virus (HIV-1) infection in populations at risk in Miami prompted a seroepidemiologic study of both HIV-1 and the human T-cell leukemia virus type I (HTLV-I), a closely related virus, in our patients receiving chronic hemodialysis. One hundred twenty-nine patients undergoing hemodialysis in 1986 and 1987 were tested for antibody against both viral antigens by EIA (Abbott Laboratories, Abbott Park, IL). Seroreactive samples for HIV-1 and HTLV-I were confirmed by Western blot and, for HTLV-I, by viral cultures. Thirty patients (23.2%) were positive for retroviral infection (22 for HIV-1 alone, four for HTLV-I alone, and four for both HIV-1 and HTLV-I). The most important risk factor was intravenous drug use, followed by blood transfusion. Patients with HIV-1 had lower T4-T8 ratios and higher mortality than those with HTLV-I infection alone. It was concluded that HTLV-I, as well as HIV-1, infection is endemic in chronic dialysis centers in Miami. The clinical consequences of HTLV-I infection in relatively immunocompromised patients with chronic uremia who are undergoing chronic hemodialysis remains to be established.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume14
Issue number1
StatePublished - Jan 1 1989

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Human T-lymphotropic virus 1
Renal Dialysis
HIV-1
Maintenance
HIV
Virus Diseases
HIV Infections
CD4-CD8 Ratio
Viral Antigens
Uremia
Seroepidemiologic Studies
Immunocompromised Host
Blood Transfusion
Dialysis
Western Blotting
Viruses
Mortality
Antibodies
Infection

ASJC Scopus subject areas

  • Nephrology

Cite this

Perez, G., Ortiz-Interian, C., Lee, H., De Medina, M., Cerney, M., Allain, J. P., ... Bourgoignie, J. J. (1989). Human immunodeficiency virus and human T-cell leukemia virus type I in patients undergoing maintenance hemodialysis in Miami. American Journal of Kidney Diseases, 14(1), 39-43.

Human immunodeficiency virus and human T-cell leukemia virus type I in patients undergoing maintenance hemodialysis in Miami. / Perez, G.; Ortiz-Interian, C.; Lee, H.; De Medina, M.; Cerney, M.; Allain, J. P.; Schiff, Eugene R; Parks, E.; Parks, W.; Bourgoignie, J. J.

In: American Journal of Kidney Diseases, Vol. 14, No. 1, 01.01.1989, p. 39-43.

Research output: Contribution to journalArticle

Perez, G, Ortiz-Interian, C, Lee, H, De Medina, M, Cerney, M, Allain, JP, Schiff, ER, Parks, E, Parks, W & Bourgoignie, JJ 1989, 'Human immunodeficiency virus and human T-cell leukemia virus type I in patients undergoing maintenance hemodialysis in Miami', American Journal of Kidney Diseases, vol. 14, no. 1, pp. 39-43.
Perez, G. ; Ortiz-Interian, C. ; Lee, H. ; De Medina, M. ; Cerney, M. ; Allain, J. P. ; Schiff, Eugene R ; Parks, E. ; Parks, W. ; Bourgoignie, J. J. / Human immunodeficiency virus and human T-cell leukemia virus type I in patients undergoing maintenance hemodialysis in Miami. In: American Journal of Kidney Diseases. 1989 ; Vol. 14, No. 1. pp. 39-43.
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