Human germinal center-associated lymphoma protein expression is associated with improved failure-free survival in Brazilian patients with classical Hodgkin lymphoma

Denize Azambuja, Izidore S. Lossos, Irene Biasoli, Jos Carlos Morais, Luciana Britto, Adriana Scheliga, Wolmar Pulcheri, Yasodha Natkunam, Nelson Spector

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The human germinal center-associated lymphoma (HGAL) gene has prognostic value in diffuse large B-cell lymphoma, and expression of its cognate protein is germinal center-specific. A previous study had suggested that HGAL protein expression might also be related to the outcome in patients with Hodgkin lymphoma (HL). The aim of this study was to confirm the prognostic impact of HGAL protein expression in an independent, well-characterized cohort of 232 patients with classic HL treated uniformly with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). Tissue microarray analysis showed HGAL staining in 188 specimens (81). Failure-free survival (FFS) was superior in patients with early-stage disease, low-risk IPS, and HGAL-positive patients. The estimated 5-year FFS for HGAL-positive and HGAL-negative patients was 82 and 67, respectively (p0.03). In the multivariate analysis, advanced stage and absence of HGAL staining were independent predictors of a worse FFS. This study confirms and validates recent findings of a correlation between HGAL expression and outcome in classical HL.

Original languageEnglish (US)
Pages (from-to)1830-1836
Number of pages7
JournalLeukemia and Lymphoma
Volume50
Issue number11
DOIs
StatePublished - Nov 2009

Keywords

  • HGAL
  • Hodgkin lymphoma
  • Prognosis
  • Survival
  • Tissue microarray

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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