Human genetic susceptibility to Candida infections

Theo S. Plantinga, Melissa D. Johnson, William K. Scott, Leo A.B. Joosten, Jos W.M. Van Der Meer, John R. Perfect, Bart Jan Kullberg, Mihai G. Netea

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Infections with Candida spp. have different manifestations in humans, ranging from mucosal to bloodstream and deep-seated disseminated infections. Immunocompromised patients have increased susceptibility to these types of infections, due to reduced capacity to elicit effective innate or adaptive immunity. In addition, rare and common genetic variants in the human genome have been identified that influence susceptibility to Candida infections. Genetic determinants of primary immunodeficiencies leading to chronic mucocutaneous candidiasis have been reported, and polymorphisms in genes that are known to be involved in anti-Candida host defense are associated with increased susceptibility to systemic infection. These findings have greatly increased our understanding of pathways important for anti-Candida defense in humans, and patterns of prevalence of Candida infections. In addition, these pathways may offer novel therapeutic targets for treatment. This review provides an overview of the current insights in genetic susceptibility to Candida infections and their consequences for the immune response against Candida.

Original languageEnglish (US)
Pages (from-to)785-794
Number of pages10
JournalMedical mycology
Volume87
Issue number8
DOIs
StatePublished - Nov 1 2012

Keywords

  • Candida
  • Candidemia
  • Chronic mucocutaneous candidiasis
  • Cytokines
  • Genetic susceptibility
  • Immunity

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

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    Plantinga, T. S., Johnson, M. D., Scott, W. K., Joosten, L. A. B., Van Der Meer, J. W. M., Perfect, J. R., Kullberg, B. J., & Netea, M. G. (2012). Human genetic susceptibility to Candida infections. Medical mycology, 87(8), 785-794. https://doi.org/10.3109/13693786.2012.690902