Human embryonic stem cell derivation from poor-quality embryos

Paul H. Lerou, Akiko Yabuuchi, Hongguang Huo, Ayumu Takeuchi, Jessica Shea, Tina Cimini, Tan A. Ince, Elizabeth Ginsburg, Catherine Racowsky, George Q. Daley

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


During in vitro fertilization, embryos deemed clinically useless based on poor morphology are typically discarded. Here we demonstrate a statistical correlation between the developmental stage of such poor-quality embryos and the yield of human embryonic stem (hES) cell lines. Early-arrested or highly fragmented embryos only rarely yield cell lines, whereas those that have achieved blastocyst stage are a robust source of normal hES cells.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
JournalNature Biotechnology
Issue number2
StatePublished - Feb 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering


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