Human chromosome 8 linkage map based on short tandem repeat polymorphisms: Effect of genotyping errors

James Tomfohrde; Stephen Wood; Michael Schertzer; Michael J. Wagner; Dan E. Wells; Julia Parrish; Lori A. Sadler; Susan H. Blanton; Stephen P. Daiger; Zhenyuan Wang; Patricia J. Wilkie; James L. Weber

doi:10.1016/S0888-7543(05)80297-6

Human chromosome 8 linkage map based on short tandem repeat polymorphisms: Effect of genotyping errors

James Tomfohrde, Stephen Wood, Michael Schertzer, Michael J. Wagner, Dan E. Wells, Julia Parrish, Lori A. Sadler, Susan H. Blanton, Stephen P. Daiger, Zhenyuan Wang, Patricia J. Wilkie, James L. Weber

Research output: Contribution to journal › Article

72 Scopus citations

Abstract

A linkage map consisting of 21 dinucleotide repeat polymorphisms, 1 tetranucleotide repeat polymorphism, and 3 RFLPs was constructed for human chromosome 8. The map spanned most of the chromosome length from near pter to q23-q24 on the distal portion of the long arm. The total 186 cM length of the female map was over two times the 84 cM length of the male map. Cytogenetic mapping of the polymorphisms using a panel of hybrids containing rearranged chromosomes was completely consistent with the linkage map. Special effort was made to remove as many genotyping errors, including parental phase errors, as possible. Removal of errors, in agreement with recent theoretical predictions, led to reduction of the total length of the sex-equal map by 10% from 145 to 130 cM.

Original language	English (US)
Pages (from-to)	144-152
Number of pages	9
Journal	Genomics
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/S0888-7543(05)80297-6
State	Published - Sep 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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Tomfohrde, J., Wood, S., Schertzer, M., Wagner, M. J., Wells, D. E., Parrish, J., Sadler, L. A., Blanton, S. H., Daiger, S. P., Wang, Z., Wilkie, P. J., & Weber, J. L. (1992). Human chromosome 8 linkage map based on short tandem repeat polymorphisms: Effect of genotyping errors. Genomics, 14(1), 144-152. https://doi.org/10.1016/S0888-7543(05)80297-6

Human chromosome 8 linkage map based on short tandem repeat polymorphisms : Effect of genotyping errors. / Tomfohrde, James; Wood, Stephen; Schertzer, Michael; Wagner, Michael J.; Wells, Dan E.; Parrish, Julia; Sadler, Lori A.; Blanton, Susan H.; Daiger, Stephen P.; Wang, Zhenyuan; Wilkie, Patricia J.; Weber, James L.

In: Genomics, Vol. 14, No. 1, 09.1992, p. 144-152.

Research output: Contribution to journal › Article

Tomfohrde, James ; Wood, Stephen ; Schertzer, Michael ; Wagner, Michael J. ; Wells, Dan E. ; Parrish, Julia ; Sadler, Lori A. ; Blanton, Susan H. ; Daiger, Stephen P. ; Wang, Zhenyuan ; Wilkie, Patricia J. ; Weber, James L. / Human chromosome 8 linkage map based on short tandem repeat polymorphisms : Effect of genotyping errors. In: Genomics. 1992 ; Vol. 14, No. 1. pp. 144-152.

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title = "Human chromosome 8 linkage map based on short tandem repeat polymorphisms: Effect of genotyping errors",

abstract = "A linkage map consisting of 21 dinucleotide repeat polymorphisms, 1 tetranucleotide repeat polymorphism, and 3 RFLPs was constructed for human chromosome 8. The map spanned most of the chromosome length from near pter to q23-q24 on the distal portion of the long arm. The total 186 cM length of the female map was over two times the 84 cM length of the male map. Cytogenetic mapping of the polymorphisms using a panel of hybrids containing rearranged chromosomes was completely consistent with the linkage map. Special effort was made to remove as many genotyping errors, including parental phase errors, as possible. Removal of errors, in agreement with recent theoretical predictions, led to reduction of the total length of the sex-equal map by 10% from 145 to 130 cM.",

author = "James Tomfohrde and Stephen Wood and Michael Schertzer and Wagner, {Michael J.} and Wells, {Dan E.} and Julia Parrish and Sadler, {Lori A.} and Blanton, {Susan H.} and Daiger, {Stephen P.} and Zhenyuan Wang and Wilkie, {Patricia J.} and Weber, {James L.}",

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AU - Wells, Dan E.

AU - Parrish, Julia

AU - Sadler, Lori A.

AU - Blanton, Susan H.

AU - Daiger, Stephen P.

AU - Wang, Zhenyuan

AU - Wilkie, Patricia J.

AU - Weber, James L.

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