Abstract
A linkage map consisting of 21 dinucleotide repeat polymorphisms, 1 tetranucleotide repeat polymorphism, and 3 RFLPs was constructed for human chromosome 8. The map spanned most of the chromosome length from near pter to q23-q24 on the distal portion of the long arm. The total 186 cM length of the female map was over two times the 84 cM length of the male map. Cytogenetic mapping of the polymorphisms using a panel of hybrids containing rearranged chromosomes was completely consistent with the linkage map. Special effort was made to remove as many genotyping errors, including parental phase errors, as possible. Removal of errors, in agreement with recent theoretical predictions, led to reduction of the total length of the sex-equal map by 10% from 145 to 130 cM.
| Original language | English |
|---|---|
| Pages (from-to) | 144-152 |
| Number of pages | 9 |
| Journal | Genomics |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Human chromosome 8 linkage map based on short tandem repeat polymorphisms : Effect of genotyping errors. / Tomfohrde, James; Wood, Stephen; Schertzer, Michael; Wagner, Michael J.; Wells, Dan E.; Parrish, Julia; Sadler, Lori A.; Blanton, Susan H; Daiger, Stephen P.; Wang, Zhenyuan; Wilkie, Patricia J.; Weber, James L.
In: Genomics, Vol. 14, No. 1, 01.01.1992, p. 144-152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human chromosome 8 linkage map based on short tandem repeat polymorphisms
T2 - Effect of genotyping errors
AU - Tomfohrde, James
AU - Wood, Stephen
AU - Schertzer, Michael
AU - Wagner, Michael J.
AU - Wells, Dan E.
AU - Parrish, Julia
AU - Sadler, Lori A.
AU - Blanton, Susan H
AU - Daiger, Stephen P.
AU - Wang, Zhenyuan
AU - Wilkie, Patricia J.
AU - Weber, James L.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - A linkage map consisting of 21 dinucleotide repeat polymorphisms, 1 tetranucleotide repeat polymorphism, and 3 RFLPs was constructed for human chromosome 8. The map spanned most of the chromosome length from near pter to q23-q24 on the distal portion of the long arm. The total 186 cM length of the female map was over two times the 84 cM length of the male map. Cytogenetic mapping of the polymorphisms using a panel of hybrids containing rearranged chromosomes was completely consistent with the linkage map. Special effort was made to remove as many genotyping errors, including parental phase errors, as possible. Removal of errors, in agreement with recent theoretical predictions, led to reduction of the total length of the sex-equal map by 10% from 145 to 130 cM.
AB - A linkage map consisting of 21 dinucleotide repeat polymorphisms, 1 tetranucleotide repeat polymorphism, and 3 RFLPs was constructed for human chromosome 8. The map spanned most of the chromosome length from near pter to q23-q24 on the distal portion of the long arm. The total 186 cM length of the female map was over two times the 84 cM length of the male map. Cytogenetic mapping of the polymorphisms using a panel of hybrids containing rearranged chromosomes was completely consistent with the linkage map. Special effort was made to remove as many genotyping errors, including parental phase errors, as possible. Removal of errors, in agreement with recent theoretical predictions, led to reduction of the total length of the sex-equal map by 10% from 145 to 130 cM.
UR - http://www.scopus.com/inward/record.url?scp=0026742493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026742493&partnerID=8YFLogxK
U2 - 10.1016/S0888-7543(05)80297-6
DO - 10.1016/S0888-7543(05)80297-6
M3 - Article
C2 - 1427821
AN - SCOPUS:0026742493
VL - 14
SP - 144
EP - 152
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 1
ER -