Human brain glucose utilization and cognitive function in relation to age

R. Duara, C. Grady, J. Haxby

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

Brain oxidative metabolism was examined with positron emission tomography and [18F]2-deoxy-D-glucose in 40 healthy men aged 21 to 83 years, under conditions of reduced visual and auditory stimulation. The mean cerebral metabolic rate for glucose (CMR(glc)) equaled 4.6 to 4.7 mg · 100 gm-1 · min-1 and did not correlate significantly with age (p > 0.05). Regional cerebral metabolic rates for glucose (rCMR(glc)) and Q ratios (rCMR(glc)/CMR(glc)), which had lower coefficients of variation than did rCMR(glc), also did not correlate with age. Hyperfrontality of cerebral metabolism was absent at all ages. Age decrements were demonstrated in the error score on the Benton Revised Visual Retention Test and in the Performance Subtest scaled score of the Wechsler Adult Intelligence Scale (WAIS) but not in the Verbal Subtest scaled score of the WAIS. The cognitive test scores did not correlate with brain metabolic rates. The results indicate that brain oxidative metabolism, when measured under resting conditions with reduced sensory input, is not reduced in relation to age in healthy men. Furthermore, no significant relations between intelligence and resting cerebral metabolism are evident.

Original languageEnglish
Pages (from-to)702-713
Number of pages12
JournalAnnals of Neurology
Volume16
Issue number6
StatePublished - Dec 1 1984
Externally publishedYes

Fingerprint

Cognition
Glucose
Intelligence
Brain
Acoustic Stimulation
Photic Stimulation
Deoxyglucose
Positron-Emission Tomography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Duara, R., Grady, C., & Haxby, J. (1984). Human brain glucose utilization and cognitive function in relation to age. Annals of Neurology, 16(6), 702-713.

Human brain glucose utilization and cognitive function in relation to age. / Duara, R.; Grady, C.; Haxby, J.

In: Annals of Neurology, Vol. 16, No. 6, 01.12.1984, p. 702-713.

Research output: Contribution to journalArticle

Duara, R, Grady, C & Haxby, J 1984, 'Human brain glucose utilization and cognitive function in relation to age', Annals of Neurology, vol. 16, no. 6, pp. 702-713.
Duara, R. ; Grady, C. ; Haxby, J. / Human brain glucose utilization and cognitive function in relation to age. In: Annals of Neurology. 1984 ; Vol. 16, No. 6. pp. 702-713.
@article{e4f3ba5fc6cc4a50bf76cccca1d6c0fd,
title = "Human brain glucose utilization and cognitive function in relation to age",
abstract = "Brain oxidative metabolism was examined with positron emission tomography and [18F]2-deoxy-D-glucose in 40 healthy men aged 21 to 83 years, under conditions of reduced visual and auditory stimulation. The mean cerebral metabolic rate for glucose (CMR(glc)) equaled 4.6 to 4.7 mg · 100 gm-1 · min-1 and did not correlate significantly with age (p > 0.05). Regional cerebral metabolic rates for glucose (rCMR(glc)) and Q ratios (rCMR(glc)/CMR(glc)), which had lower coefficients of variation than did rCMR(glc), also did not correlate with age. Hyperfrontality of cerebral metabolism was absent at all ages. Age decrements were demonstrated in the error score on the Benton Revised Visual Retention Test and in the Performance Subtest scaled score of the Wechsler Adult Intelligence Scale (WAIS) but not in the Verbal Subtest scaled score of the WAIS. The cognitive test scores did not correlate with brain metabolic rates. The results indicate that brain oxidative metabolism, when measured under resting conditions with reduced sensory input, is not reduced in relation to age in healthy men. Furthermore, no significant relations between intelligence and resting cerebral metabolism are evident.",
author = "R. Duara and C. Grady and J. Haxby",
year = "1984",
month = "12",
day = "1",
language = "English",
volume = "16",
pages = "702--713",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Human brain glucose utilization and cognitive function in relation to age

AU - Duara, R.

AU - Grady, C.

AU - Haxby, J.

PY - 1984/12/1

Y1 - 1984/12/1

N2 - Brain oxidative metabolism was examined with positron emission tomography and [18F]2-deoxy-D-glucose in 40 healthy men aged 21 to 83 years, under conditions of reduced visual and auditory stimulation. The mean cerebral metabolic rate for glucose (CMR(glc)) equaled 4.6 to 4.7 mg · 100 gm-1 · min-1 and did not correlate significantly with age (p > 0.05). Regional cerebral metabolic rates for glucose (rCMR(glc)) and Q ratios (rCMR(glc)/CMR(glc)), which had lower coefficients of variation than did rCMR(glc), also did not correlate with age. Hyperfrontality of cerebral metabolism was absent at all ages. Age decrements were demonstrated in the error score on the Benton Revised Visual Retention Test and in the Performance Subtest scaled score of the Wechsler Adult Intelligence Scale (WAIS) but not in the Verbal Subtest scaled score of the WAIS. The cognitive test scores did not correlate with brain metabolic rates. The results indicate that brain oxidative metabolism, when measured under resting conditions with reduced sensory input, is not reduced in relation to age in healthy men. Furthermore, no significant relations between intelligence and resting cerebral metabolism are evident.

AB - Brain oxidative metabolism was examined with positron emission tomography and [18F]2-deoxy-D-glucose in 40 healthy men aged 21 to 83 years, under conditions of reduced visual and auditory stimulation. The mean cerebral metabolic rate for glucose (CMR(glc)) equaled 4.6 to 4.7 mg · 100 gm-1 · min-1 and did not correlate significantly with age (p > 0.05). Regional cerebral metabolic rates for glucose (rCMR(glc)) and Q ratios (rCMR(glc)/CMR(glc)), which had lower coefficients of variation than did rCMR(glc), also did not correlate with age. Hyperfrontality of cerebral metabolism was absent at all ages. Age decrements were demonstrated in the error score on the Benton Revised Visual Retention Test and in the Performance Subtest scaled score of the Wechsler Adult Intelligence Scale (WAIS) but not in the Verbal Subtest scaled score of the WAIS. The cognitive test scores did not correlate with brain metabolic rates. The results indicate that brain oxidative metabolism, when measured under resting conditions with reduced sensory input, is not reduced in relation to age in healthy men. Furthermore, no significant relations between intelligence and resting cerebral metabolism are evident.

UR - http://www.scopus.com/inward/record.url?scp=0021700808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021700808&partnerID=8YFLogxK

M3 - Article

C2 - 6335379

AN - SCOPUS:0021700808

VL - 16

SP - 702

EP - 713

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 6

ER -