Human B cell senescence in pulmonary infections

Bonnie B. Blomberg, Daniela Frasca, Deborah Dunn-Walters

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Vaccinations are powerful tools to help prevent/minimize the consequences of infections. Currently available vaccines are protecting only part of the human population because of the agerelated decrease in immune functions. Vaccination against Streptococcus pneumoniae and influenza are strongly recommended in children under 2 years of age and individuals over 65 years of age to protect them from infection. However, although commercially available vaccines against these infectious diseases provide protection and ensure lasting immunological memory in children and adults, they are much less effective in elderly individuals. The mechanisms for the reduced response of the elderly to pneumococcal and influenza vaccines are discussed in this review from the perspective of deficiencies seen in B cell function with age.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalOpen Longevity Science
Volume6
DOIs
StatePublished - 2012

Keywords

  • Aging
  • B cells
  • Influenza
  • Pneumococcus

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Aging

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