Human aqueous humor penetration of systemic administration of fluconazole

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Purpoic: To establish the aqueous humor levels of systemic administered Fluconazole. Methods: Patients with fungal keratitis receiving systemic Fluconazole 200 mg./day had aqueous humor levels of Fluconazole determined at the time of penetrating keratoplasty. Fluconazole levels were determined by high pressure liquid chromatography. Resuts: Eight patients were studied. In patients receiving the last dose of oral Fluconazole 200 mg, 24 hours prior to measurement, the aqueous levels ranged from 2.5 to 16.8 ug/ml. When the oral dose was given between 12-24 hours before measurement, the levels ranged from 3.1 to 4.6 ug/ml. In a patient receiving the dose 2 hours before, the level was 25.1 ug/ml. The aqueous levels of Fluconazole were below the minimum inhibitory concentrations(MIC) for six of the eight organisms cultured from the cornea. The levels were adequate for C. albicans. but below the MIC for Fasarium, Acremonium, and Paecilomyces. Conclusions: Therapeutic levels of Fluconazole can be achieved in the aqueous humor of humans after oral administration of Fluconazole 200 mg/day for C. albicans but may not be sufficiently elevated for filamentous fungi. Supported by Research to Prevent Blindness.

Original languageEnglish (US)
Pages (from-to)S142
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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