Abstract
Enhancing β-Cell proliferation is a major goal for type 1 and type 2 diabetes research. Unraveling the network of β-Cell intracellular signaling pathways that promote β-Cell replication can provide the tools to address this important task. In a previous Perspectives in Diabetes article, we discussed what was known regarding several important intracellular signaling pathways in rodent β-Cells, including the insulin receptor substrate/phosphatidylinositol-3 kinase/Akt (IRS-PI3K-Akt) pathways, glycogen synthase kinase-3 (GSK3) and mammalian target of rapamycin (mTOR) S6 kinase pathways, protein kinase Cz (PKCz) pathways, and their downstream cell-cycle molecular targets, and contrasted that ample knowledge to the small amount of complementary data on human β-Cell intracellular signaling pathways. In this Perspectives, we summarize additional important information on signaling pathways activated by nutrients, such as glucose; growth factors, such as epidermal growth factor, platelet-derived growth factor, and Wnt; and hormones, such as leptin, estrogen, and progesterone, that are linked to rodent and human β-Cell proliferation. With these two Perspectives, we attempt to construct a brief summary of knowledge for β-Cell researchers on mitogenic signaling pathways and to emphasize how little is known regarding intracellular events linked to human β-Cell replication. This is a critical aspect in the long-term goal of expanding human β-Cells for the prevention and/or cure of type 1 and type 2 diabetes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 819-831 |
| Number of pages | 13 |
| Journal | Diabetes |
| Volume | 63 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2014 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Human β-cell proliferation and intracellular signaling part 2 : Still driving in the dark without a road map. / Bernal Mizrachi, Ernesto; Kulkarni, Rohit N.; Scott, Donald K.; Mauvais-Jarvis, Franck; Stewart, Andrew F.; Garcia-Ocaña, Adolfo.
In: Diabetes, Vol. 63, No. 3, 03.2014, p. 819-831.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human β-cell proliferation and intracellular signaling part 2
T2 - Still driving in the dark without a road map
AU - Bernal Mizrachi, Ernesto
AU - Kulkarni, Rohit N.
AU - Scott, Donald K.
AU - Mauvais-Jarvis, Franck
AU - Stewart, Andrew F.
AU - Garcia-Ocaña, Adolfo
PY - 2014/3
Y1 - 2014/3
N2 - Enhancing β-Cell proliferation is a major goal for type 1 and type 2 diabetes research. Unraveling the network of β-Cell intracellular signaling pathways that promote β-Cell replication can provide the tools to address this important task. In a previous Perspectives in Diabetes article, we discussed what was known regarding several important intracellular signaling pathways in rodent β-Cells, including the insulin receptor substrate/phosphatidylinositol-3 kinase/Akt (IRS-PI3K-Akt) pathways, glycogen synthase kinase-3 (GSK3) and mammalian target of rapamycin (mTOR) S6 kinase pathways, protein kinase Cz (PKCz) pathways, and their downstream cell-cycle molecular targets, and contrasted that ample knowledge to the small amount of complementary data on human β-Cell intracellular signaling pathways. In this Perspectives, we summarize additional important information on signaling pathways activated by nutrients, such as glucose; growth factors, such as epidermal growth factor, platelet-derived growth factor, and Wnt; and hormones, such as leptin, estrogen, and progesterone, that are linked to rodent and human β-Cell proliferation. With these two Perspectives, we attempt to construct a brief summary of knowledge for β-Cell researchers on mitogenic signaling pathways and to emphasize how little is known regarding intracellular events linked to human β-Cell replication. This is a critical aspect in the long-term goal of expanding human β-Cells for the prevention and/or cure of type 1 and type 2 diabetes.
AB - Enhancing β-Cell proliferation is a major goal for type 1 and type 2 diabetes research. Unraveling the network of β-Cell intracellular signaling pathways that promote β-Cell replication can provide the tools to address this important task. In a previous Perspectives in Diabetes article, we discussed what was known regarding several important intracellular signaling pathways in rodent β-Cells, including the insulin receptor substrate/phosphatidylinositol-3 kinase/Akt (IRS-PI3K-Akt) pathways, glycogen synthase kinase-3 (GSK3) and mammalian target of rapamycin (mTOR) S6 kinase pathways, protein kinase Cz (PKCz) pathways, and their downstream cell-cycle molecular targets, and contrasted that ample knowledge to the small amount of complementary data on human β-Cell intracellular signaling pathways. In this Perspectives, we summarize additional important information on signaling pathways activated by nutrients, such as glucose; growth factors, such as epidermal growth factor, platelet-derived growth factor, and Wnt; and hormones, such as leptin, estrogen, and progesterone, that are linked to rodent and human β-Cell proliferation. With these two Perspectives, we attempt to construct a brief summary of knowledge for β-Cell researchers on mitogenic signaling pathways and to emphasize how little is known regarding intracellular events linked to human β-Cell replication. This is a critical aspect in the long-term goal of expanding human β-Cells for the prevention and/or cure of type 1 and type 2 diabetes.
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UR - http://www.scopus.com/inward/citedby.url?scp=84894454462&partnerID=8YFLogxK
U2 - 10.2337/db13-1146
DO - 10.2337/db13-1146
M3 - Article
C2 - 24556859
AN - SCOPUS:84894454462
VL - 63
SP - 819
EP - 831
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 3
ER -