Human β-cell proliferation and intracellular signaling: Driving in the dark without a road map

Rohit N. Kulkarni, Ernesto Bernal Mizrachi, Adolfo Garcia Ocana, Andrew F. Stewart

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations

Abstract

A major goal in diabetes research is to find ways to enhance the mass and function of insulin secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even reverse overt diabetes. In this Perspectives in Diabetes article, we highlight the contrast between the relatively large body of information that is available in regard to signaling pathways, proteins, and mechanisms that together provide a road map for efforts to regenerate β-cells in rodents versus the scant information in human β-cells. To reverse the state of ignorance regarding human β-cell signaling, we suggest a series of questions for consideration by the scientific community to construct a human β-cell proliferation road map. The hope is that the knowledge from the new studies will allow the community to move faster towards developing therapeutic approaches to enhance human β-cell mass in the long-term goal of preventing and/or curing type 1 and type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)2205-2213
Number of pages9
JournalDiabetes
Volume61
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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