HTLV-III infection in brains of children and adults with AIDS encephalopathy

G. M. Shaw, M. E. Harper, B. H. Hahn, L. G. Epstein, D. C. Gajdusek, R. W. Price, B. A. Navia, Carol Petito, C. J. O'Hara, J. E. Groopman

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Abstract

Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS. HTLV-III DNA was detected in the brains of five patients, and viral-specific RNA was detected in four of these. In view of these findings and the recent demonstration of morphologic and genetic relatedness between HTLV-III and visna virus, a lentivirus that causes a chronic degenerative neurologic disease in sheep, HTLV-III should be evaluated further as a possible cause of AIDS encephalopathy.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalScience
Volume227
Issue number4683
DOIs
StatePublished - Mar 27 1985
Externally publishedYes

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Brain Diseases
HIV Infections
Acquired Immunodeficiency Syndrome
HIV
Brain
Deltaretrovirus
Visna-maedi virus
Lentivirus
Viral RNA
Neurodegenerative Diseases
In Situ Hybridization
Dementia
Sheep
DNA

ASJC Scopus subject areas

  • General

Cite this

Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Gajdusek, D. C., Price, R. W., ... Groopman, J. E. (1985). HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science, 227(4683), 177-182. https://doi.org/10.1126/science.2981429

HTLV-III infection in brains of children and adults with AIDS encephalopathy. / Shaw, G. M.; Harper, M. E.; Hahn, B. H.; Epstein, L. G.; Gajdusek, D. C.; Price, R. W.; Navia, B. A.; Petito, Carol; O'Hara, C. J.; Groopman, J. E.

In: Science, Vol. 227, No. 4683, 27.03.1985, p. 177-182.

Research output: Contribution to journalArticle

Shaw, GM, Harper, ME, Hahn, BH, Epstein, LG, Gajdusek, DC, Price, RW, Navia, BA, Petito, C, O'Hara, CJ & Groopman, JE 1985, 'HTLV-III infection in brains of children and adults with AIDS encephalopathy', Science, vol. 227, no. 4683, pp. 177-182. https://doi.org/10.1126/science.2981429
Shaw GM, Harper ME, Hahn BH, Epstein LG, Gajdusek DC, Price RW et al. HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science. 1985 Mar 27;227(4683):177-182. https://doi.org/10.1126/science.2981429
Shaw, G. M. ; Harper, M. E. ; Hahn, B. H. ; Epstein, L. G. ; Gajdusek, D. C. ; Price, R. W. ; Navia, B. A. ; Petito, Carol ; O'Hara, C. J. ; Groopman, J. E. / HTLV-III infection in brains of children and adults with AIDS encephalopathy. In: Science. 1985 ; Vol. 227, No. 4683. pp. 177-182.
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