HTLV-III infection in brains of children and adults with AIDS encephalopathy

George M. Shaw, Mary E. Harper, Beatrice H. Hahn, Leon G. Epstein, D. Carleton Gajdusek, Richard W. Price, Bradford A. Navia, Carol K. Petito, Carl J. O'Hara, Jerome E. Groopman, Eun Sook Cho, James M. Oleske, Flossie Wong-Staal, Robert C. Gallo

Research output: Contribution to journalArticle

618 Scopus citations

Abstract

Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS. HTLV-III DNA was detected in the brains of five patients, and viral-specific RNA was detected in four of these. In view of these findings and the recent demonstration of morphologic and genetic relatedness between HTLV-III and visna virus, a lentivirus that causes a chronic degenerative neurologic disease in sheep, HTLV-III should be evaluated further as a possible cause of AIDS encephalopathy.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalScience
Volume227
Issue number4683
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'HTLV-III infection in brains of children and adults with AIDS encephalopathy'. Together they form a unique fingerprint.

  • Cite this

    Shaw, G. M., Harper, M. E., Hahn, B. H., Epstein, L. G., Carleton Gajdusek, D., Price, R. W., Navia, B. A., Petito, C. K., O'Hara, C. J., Groopman, J. E., Cho, E. S., Oleske, J. M., Wong-Staal, F., & Gallo, R. C. (1985). HTLV-III infection in brains of children and adults with AIDS encephalopathy. Science, 227(4683), 177-182. https://doi.org/10.1126/science.2981429