HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes

Joseph D Rosenblatt, A. J. Cann, D. J. Slamon, I. S. Smalberg, N. P. Shah, J. Fujii, W. Wachsman, I. S Y Chen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.

Original languageEnglish
Pages (from-to)916-919
Number of pages4
JournalScience
Volume240
Issue number4854
StatePublished - Jan 1 1988
Externally publishedYes

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pX Genes
Human T-lymphotropic virus 2
Transcriptional Activation
Genes
Reading Frames
Human T-lymphotropic virus 1
Terminal Repeat Sequences
Life Cycle Stages
Proteins

ASJC Scopus subject areas

  • General

Cite this

Rosenblatt, J. D., Cann, A. J., Slamon, D. J., Smalberg, I. S., Shah, N. P., Fujii, J., ... Chen, I. S. Y. (1988). HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes. Science, 240(4854), 916-919.

HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes. / Rosenblatt, Joseph D; Cann, A. J.; Slamon, D. J.; Smalberg, I. S.; Shah, N. P.; Fujii, J.; Wachsman, W.; Chen, I. S Y.

In: Science, Vol. 240, No. 4854, 01.01.1988, p. 916-919.

Research output: Contribution to journalArticle

Rosenblatt, JD, Cann, AJ, Slamon, DJ, Smalberg, IS, Shah, NP, Fujii, J, Wachsman, W & Chen, ISY 1988, 'HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes', Science, vol. 240, no. 4854, pp. 916-919.
Rosenblatt JD, Cann AJ, Slamon DJ, Smalberg IS, Shah NP, Fujii J et al. HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes. Science. 1988 Jan 1;240(4854):916-919.
Rosenblatt, Joseph D ; Cann, A. J. ; Slamon, D. J. ; Smalberg, I. S. ; Shah, N. P. ; Fujii, J. ; Wachsman, W. ; Chen, I. S Y. / HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes. In: Science. 1988 ; Vol. 240, No. 4854. pp. 916-919.
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