HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes

Joseph D. Rosenblatt, Alan J. Cann, Dennis J. Slamon, Ira S. Smalberg, Neil P. Shah, Joyce Fujii, William Wachsman, Irvin S.Y. Chen

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.

Original languageEnglish (US)
Pages (from-to)916-919
Number of pages4
JournalScience
Volume240
Issue number4854
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • General

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    Rosenblatt, J. D., Cann, A. J., Slamon, D. J., Smalberg, I. S., Shah, N. P., Fujii, J., Wachsman, W., & Chen, I. S. Y. (1988). HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes. Science, 240(4854), 916-919. https://doi.org/10.1126/science.2834826