HPV prevalence among mexican women with neoplastic and normal cervixes

Marta Torroella-Kouri, Steven Morsberger, Adela Carrillo, Alejandro Mohar, Abelardo Meneses, Margarita Ibarra, Richard W. Daniel, Anthony M. Ghaffari, Gilberto Solorza, Keerti V. Shah

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Genital human papillomavirus (HPV) infection is causally linked to cervical cancer, yet little is known regarding HPV prevalence in cancerous and normal women in Mexico, a country with a high cervical cancer incidence. We studied 185 Mexican women among the patients attending gynecological outpatient clinics in four hospitals in Mexico City. Each woman had a Pap smear, a colposcopy, and, when necessary, a biopsy. HPVs were identified by a consensus-primer-based polymerase chain reaction (PCR) assay. HPV was detected in 87% of 69 cancers, 83% of 24 high-grade squamous intraepithelial lesions (HGSILs), 33% of 21 low-grade squamous intraepithelial lesions (LGSILs), and 17% of 71 normals. Twenty-one of the 32 HPV types tested were detected at least once. The ratio of high-risk:low-risk types was 87:6 in HGSILs and cancers, compared to 11:8 for LGSILs and normals. In invasive cancers, HPV types found at the highest frequency were, in descending order: HPV-16, -18, and -45, followed by -39, -59, and -58 with the same frequency. HPV-16 and related types were present in 52% of the cancer cases, as well as in 79% of HGSILs, and HPV-18 and related types were present in 36% of the cancers but in only 12.5% of the HGSILs. HPV-16 was predominant in squamous carcinomas, and HPV-18 and related types were predominant in adenosquamous carcinoma. Both biopsies and scrapes were tested for HPVs in 63 women, all of them with cervical neoplasia. Identical HPV results were obtained in 89% of the samples, but additional types were often identified in scrapes. HPV prevalence and type distribution in cervical cancer in Mexico was similar to that reported worldwide, as well as in other Latin American countries.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalGynecologic Oncology
Volume70
Issue number1
DOIs
StatePublished - Jul 1 1998
Externally publishedYes

Fingerprint

Cervix Uteri
Human papillomavirus 18
Human papillomavirus 16
Mexico
Uterine Cervical Neoplasms
Neoplasms
Adenosquamous Carcinoma
Biopsy
Papanicolaou Test
Colposcopy
Papillomavirus Infections
Ambulatory Care Facilities
Squamous Intraepithelial Lesions of the Cervix
Squamous Cell Carcinoma
Odds Ratio
Polymerase Chain Reaction
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Torroella-Kouri, M., Morsberger, S., Carrillo, A., Mohar, A., Meneses, A., Ibarra, M., ... Shah, K. V. (1998). HPV prevalence among mexican women with neoplastic and normal cervixes. Gynecologic Oncology, 70(1), 115-120. https://doi.org/10.1006/gyno.1998.5055

HPV prevalence among mexican women with neoplastic and normal cervixes. / Torroella-Kouri, Marta; Morsberger, Steven; Carrillo, Adela; Mohar, Alejandro; Meneses, Abelardo; Ibarra, Margarita; Daniel, Richard W.; Ghaffari, Anthony M.; Solorza, Gilberto; Shah, Keerti V.

In: Gynecologic Oncology, Vol. 70, No. 1, 01.07.1998, p. 115-120.

Research output: Contribution to journalArticle

Torroella-Kouri, M, Morsberger, S, Carrillo, A, Mohar, A, Meneses, A, Ibarra, M, Daniel, RW, Ghaffari, AM, Solorza, G & Shah, KV 1998, 'HPV prevalence among mexican women with neoplastic and normal cervixes', Gynecologic Oncology, vol. 70, no. 1, pp. 115-120. https://doi.org/10.1006/gyno.1998.5055
Torroella-Kouri M, Morsberger S, Carrillo A, Mohar A, Meneses A, Ibarra M et al. HPV prevalence among mexican women with neoplastic and normal cervixes. Gynecologic Oncology. 1998 Jul 1;70(1):115-120. https://doi.org/10.1006/gyno.1998.5055
Torroella-Kouri, Marta ; Morsberger, Steven ; Carrillo, Adela ; Mohar, Alejandro ; Meneses, Abelardo ; Ibarra, Margarita ; Daniel, Richard W. ; Ghaffari, Anthony M. ; Solorza, Gilberto ; Shah, Keerti V. / HPV prevalence among mexican women with neoplastic and normal cervixes. In: Gynecologic Oncology. 1998 ; Vol. 70, No. 1. pp. 115-120.
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abstract = "Genital human papillomavirus (HPV) infection is causally linked to cervical cancer, yet little is known regarding HPV prevalence in cancerous and normal women in Mexico, a country with a high cervical cancer incidence. We studied 185 Mexican women among the patients attending gynecological outpatient clinics in four hospitals in Mexico City. Each woman had a Pap smear, a colposcopy, and, when necessary, a biopsy. HPVs were identified by a consensus-primer-based polymerase chain reaction (PCR) assay. HPV was detected in 87{\%} of 69 cancers, 83{\%} of 24 high-grade squamous intraepithelial lesions (HGSILs), 33{\%} of 21 low-grade squamous intraepithelial lesions (LGSILs), and 17{\%} of 71 normals. Twenty-one of the 32 HPV types tested were detected at least once. The ratio of high-risk:low-risk types was 87:6 in HGSILs and cancers, compared to 11:8 for LGSILs and normals. In invasive cancers, HPV types found at the highest frequency were, in descending order: HPV-16, -18, and -45, followed by -39, -59, and -58 with the same frequency. HPV-16 and related types were present in 52{\%} of the cancer cases, as well as in 79{\%} of HGSILs, and HPV-18 and related types were present in 36{\%} of the cancers but in only 12.5{\%} of the HGSILs. HPV-16 was predominant in squamous carcinomas, and HPV-18 and related types were predominant in adenosquamous carcinoma. Both biopsies and scrapes were tested for HPVs in 63 women, all of them with cervical neoplasia. Identical HPV results were obtained in 89{\%} of the samples, but additional types were often identified in scrapes. HPV prevalence and type distribution in cervical cancer in Mexico was similar to that reported worldwide, as well as in other Latin American countries.",
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