Abstract
Two stimulating microelectrodes were inserted 0.5 mm apart in the rat's nucleus raphe magnus (NRM), giving a joint electrical threshold for suppression of the heat-evoked tail-flick reflex. Synchronous stimulation often required more current than predicted by consideration of each site's solitary threshold. Asynchronous stimulation required yet more current. We postulate that some NRM cells, perhaps corresponding to the 'on-cells' found previously by microelectrode recording, facilitate flexion and become relatively more influential at higher stimulus currents. We also postulate that the dominating cells that suppress flexion, possibly 'off-cells', operate optimally when firing simultaneously.
| Original language | English |
|---|---|
| Pages (from-to) | 141-146 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 90 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jul 19 1988 |
| Externally published | Yes |
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Keywords
- Firing synchronicity
- Nucleus raphe magnus
- Stimulus-produced analgesia
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
How two sites in the rat's nucleus raphe magnus interact to inhibit the tail-flick reflex. / Hentall, Ian; Fields, Howard L.
In: Neuroscience Letters, Vol. 90, No. 1-2, 19.07.1988, p. 141-146.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How two sites in the rat's nucleus raphe magnus interact to inhibit the tail-flick reflex
AU - Hentall, Ian
AU - Fields, Howard L.
PY - 1988/7/19
Y1 - 1988/7/19
N2 - Two stimulating microelectrodes were inserted 0.5 mm apart in the rat's nucleus raphe magnus (NRM), giving a joint electrical threshold for suppression of the heat-evoked tail-flick reflex. Synchronous stimulation often required more current than predicted by consideration of each site's solitary threshold. Asynchronous stimulation required yet more current. We postulate that some NRM cells, perhaps corresponding to the 'on-cells' found previously by microelectrode recording, facilitate flexion and become relatively more influential at higher stimulus currents. We also postulate that the dominating cells that suppress flexion, possibly 'off-cells', operate optimally when firing simultaneously.
AB - Two stimulating microelectrodes were inserted 0.5 mm apart in the rat's nucleus raphe magnus (NRM), giving a joint electrical threshold for suppression of the heat-evoked tail-flick reflex. Synchronous stimulation often required more current than predicted by consideration of each site's solitary threshold. Asynchronous stimulation required yet more current. We postulate that some NRM cells, perhaps corresponding to the 'on-cells' found previously by microelectrode recording, facilitate flexion and become relatively more influential at higher stimulus currents. We also postulate that the dominating cells that suppress flexion, possibly 'off-cells', operate optimally when firing simultaneously.
KW - Firing synchronicity
KW - Nucleus raphe magnus
KW - Stimulus-produced analgesia
UR - http://www.scopus.com/inward/record.url?scp=0023904114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023904114&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(88)90801-4
DO - 10.1016/0304-3940(88)90801-4
M3 - Article
C2 - 3412634
AN - SCOPUS:0023904114
VL - 90
SP - 141
EP - 146
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -