How tumors escape immune destruction and what we can do about it

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116 Scopus citations

Abstract

There is strong circumstantial evidence that tumor progression in cancer patients is controlled by the immune system. As will be detailed below, this conclusion is based on observations that tumor progression is often associated with secretion of immune suppressive factors and/or downregulation of MHC class I antigen presentation functions. The inference is that tumors must have elaborated strategies to circumvent an apparently effective immune response. Importantly, a tumor-specific immune response cannot be detected in most individuals. While this failure is in part technical, it also suggests that the magnitude of the immune responses to which tumors have to respond is low. This raises the concern, which is the underlying theme of this commentary, that a more robust immune response elicited by deliberate vaccination will exacerbate the rate of immune escape and nullify the potential benefits of immune-based therapies.

Original languageEnglish (US)
Pages (from-to)382-385
Number of pages4
JournalCancer Immunology Immunotherapy
Volume48
Issue number7
DOIs
StatePublished - Oct 12 1999
Externally publishedYes

Keywords

  • Cancer immunotherapy
  • Immune escape
  • Tumors

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • Oncology

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