How late-life depression affects cognition

Neural mechanisms

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Late-life depression is a major health problem and a significant cause of dysfunction that warrants closer evaluation and study. In contrast to younger depressed patients, most depressed older adults suffer more severe variants of the disorder, including significant cognitive impairments. These cognitive changes add to the severity of symptoms and disability that older depressed patients face and likely reflect compromise of certain neural circuits, linking cognitive impairment to late-life depression. Studies examining clinical correlates, neuropsychological testing, and functional and anatomic imaging have yielded a clearer understanding of the neural mechanisms underlying cognitive deficits in late-life depression. This article discusses cognitive impairment in geriatric depression and how developing a better understanding of its neural correlates may lead to improved understanding and outcome of this specific disorder.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalCurrent Psychiatry Reports
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2010

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Cognition
Depression
Geriatrics
Health
Cognitive Dysfunction

Keywords

  • Cognition
  • Depression
  • Geriatric

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

How late-life depression affects cognition : Neural mechanisms. / Crocco, Elizabeth; Castro, Kenia; Loewenstein, David.

In: Current Psychiatry Reports, Vol. 12, No. 1, 01.02.2010, p. 34-38.

Research output: Contribution to journalArticle

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