How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

Allison E. Aiello, Yen Ling Chiu, Daniela Frasca

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and well-being is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action. This imperative is even higher among individuals living in socioeconomically disadvantaged settings and those exposed to high levels of chronic psychosocial stress.

Original languageEnglish (US)
Pages (from-to)261-271
Number of pages11
JournalGeroScience
Volume39
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

Cytomegalovirus
Vaccines
Health
Vulnerable Populations
Poverty
Autoimmunity
Research
Type 2 Diabetes Mellitus
Vaccination
Cardiovascular Diseases
Public Health
Population
Neoplasms

Keywords

  • Aging
  • Chronic disease
  • CMV
  • Immunity
  • Socioeconomic
  • Vaccination

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms? / Aiello, Allison E.; Chiu, Yen Ling; Frasca, Daniela.

In: GeroScience, Vol. 39, No. 3, 01.06.2017, p. 261-271.

Research output: Contribution to journalReview article

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abstract = "Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and well-being is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action. This imperative is even higher among individuals living in socioeconomically disadvantaged settings and those exposed to high levels of chronic psychosocial stress.",
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