How defective spermatogenesis affects sperm DNA integrity

Manish Kuchakulla, Manish Narasimman, Kajal Khodamoradi, Zahra Khosravizadeh, Ranjith Ramasamy

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Spermatogenesis is the essential process to maintain and promote male fertility. It is extraordinarily complex with many regulatory elements and numerous steps. The process involves several cell types, regulatory molecules, repair mechanisms and epigenetic regulators. Evidence has shown that fertility can be negatively impacted by reduced sperm DNA integrity. Sources of sperm DNA damage include replication errors and causes of DNA fragmentation which include abortive apoptosis, defective maturation and oxidative stress. This review outlines the process of spermatogenesis, spermatogonial regulation and sperm differentiation; additionally, DNA damage and currently studied DNA repair mechanisms in spermatozoon are also covered.

Original languageEnglish (US)
Article numbere13615
Issue number1
StatePublished - Feb 2021


  • chromatin remodelling
  • sperm DNA damage
  • sperm DNA repair mechanisms
  • spermatogenesis
  • spermatogenesis regulation

ASJC Scopus subject areas

  • Endocrinology
  • Urology


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