Abstract
Ribonucleases (RNases) play an essential role in essentially every aspect of RNA metabolism, but they also can be destructive enzymes that need to be regulated to avoid unwanted degradation of RNA molecules. As a consequence, cells have evolved multiple strategies to protect RNAs against RNase action. They also utilize a variety of mechanisms to regulate the RNases themselves. These include post-transcriptional regulation, post-translational modification, trans-acting inhibitors, cellular localization, as well as others that are less well studied. In this review, I will briefly discuss how RNA molecules are protected and then examine in detail our current understanding of the mechanisms known to regulate individual RNases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 350-361 |
| Number of pages | 12 |
| Journal | FEMS Microbiology Reviews |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2015 |
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Keywords
- Cellular localization
- Endoribonuclease
- Exoribonuclease
- Post-translational modification
- RNA protection
ASJC Scopus subject areas
- Microbiology
- Infectious Diseases
Cite this
How bacterial cells keep ribonucleases under control. / Deutscher, Murray P.
In: FEMS Microbiology Reviews, Vol. 39, No. 3, 2015, p. 350-361.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How bacterial cells keep ribonucleases under control
AU - Deutscher, Murray P
PY - 2015
Y1 - 2015
N2 - Ribonucleases (RNases) play an essential role in essentially every aspect of RNA metabolism, but they also can be destructive enzymes that need to be regulated to avoid unwanted degradation of RNA molecules. As a consequence, cells have evolved multiple strategies to protect RNAs against RNase action. They also utilize a variety of mechanisms to regulate the RNases themselves. These include post-transcriptional regulation, post-translational modification, trans-acting inhibitors, cellular localization, as well as others that are less well studied. In this review, I will briefly discuss how RNA molecules are protected and then examine in detail our current understanding of the mechanisms known to regulate individual RNases.
AB - Ribonucleases (RNases) play an essential role in essentially every aspect of RNA metabolism, but they also can be destructive enzymes that need to be regulated to avoid unwanted degradation of RNA molecules. As a consequence, cells have evolved multiple strategies to protect RNAs against RNase action. They also utilize a variety of mechanisms to regulate the RNases themselves. These include post-transcriptional regulation, post-translational modification, trans-acting inhibitors, cellular localization, as well as others that are less well studied. In this review, I will briefly discuss how RNA molecules are protected and then examine in detail our current understanding of the mechanisms known to regulate individual RNases.
KW - Cellular localization
KW - Endoribonuclease
KW - Exoribonuclease
KW - Post-translational modification
KW - RNA protection
UR - http://www.scopus.com/inward/record.url?scp=84949198016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949198016&partnerID=8YFLogxK
U2 - 10.1093/femsre/fuv012
DO - 10.1093/femsre/fuv012
M3 - Article
VL - 39
SP - 350
EP - 361
JO - FEMS Microbiology Reviews
JF - FEMS Microbiology Reviews
SN - 0168-6445
IS - 3
ER -