How bacterial cells keep ribonucleases under control

Murray P Deutscher

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Ribonucleases (RNases) play an essential role in essentially every aspect of RNA metabolism, but they also can be destructive enzymes that need to be regulated to avoid unwanted degradation of RNA molecules. As a consequence, cells have evolved multiple strategies to protect RNAs against RNase action. They also utilize a variety of mechanisms to regulate the RNases themselves. These include post-transcriptional regulation, post-translational modification, trans-acting inhibitors, cellular localization, as well as others that are less well studied. In this review, I will briefly discuss how RNA molecules are protected and then examine in detail our current understanding of the mechanisms known to regulate individual RNases.

Original languageEnglish (US)
Pages (from-to)350-361
Number of pages12
JournalFEMS Microbiology Reviews
Volume39
Issue number3
DOIs
StatePublished - 2015

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Keywords

  • Cellular localization
  • Endoribonuclease
  • Exoribonuclease
  • Post-translational modification
  • RNA protection

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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