How, and from which cell sources, do nevi really develop?

James M. Grichnik, Andrew L. Ross, Samantha L. Schneider, Margaret I. Sanchez, Mark S. Eller, Konstantinos E. Hatzistergos

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Melanocytic neoplasms are a diverse group of benign and malignant tumors with variable clinical features. While some models still promote the epidermal melanocyte as the origin of melanocytic neoplasms, clinical findings are inconsistent with this theory for the majority of tumors. Despite advances in naevus and melanoma biology, the location and differentiation status of the cell of origin remains undefined. Germ line genetics, biological state and cellular location of the mutated cell, as well as local environmental factors all likely play a role in the development of melanocytic neoplasms. Herein, we will review potential models for melanocytic neoplasia and discuss research challenges and opportunities.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalExperimental dermatology
Volume23
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Melanoblast
  • Melanocytic stem cell
  • Melanoma stem cell
  • Melanomagenesis
  • Nevogenesis

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

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