HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Huacheng Luo, Ganqian Zhu, Jianfeng Xu, Qian Lai, Bowen Yan, Ying Guo, Tsz Kan Fung, Bernd B. Zeisig, Ya Cui, Jie Zha, Christopher Cogle, Fei Wang, Bing Xu, Feng Chun Yang, Wei Li, Chi Wai Eric So, Yi Qiu, Mingjiang Xu, Suming Huang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.

Original languageEnglish (US)
Pages (from-to)645-659.e8
JournalCancer Cell
Volume36
Issue number6
DOIs
StatePublished - Dec 9 2019
Externally publishedYes

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Keywords

  • chromatin domain
  • CTCF boundary
  • enhancer/promoter accessibility
  • HOTTIP lncRNA
  • HOTTIP transgenic mice
  • HOX and hematopoietic gene regulation
  • HSC self-renewal
  • leukemia
  • WNT signaling targets

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Luo, H., Zhu, G., Xu, J., Lai, Q., Yan, B., Guo, Y., Fung, T. K., Zeisig, B. B., Cui, Y., Zha, J., Cogle, C., Wang, F., Xu, B., Yang, F. C., Li, W., So, C. W. E., Qiu, Y., Xu, M., & Huang, S. (2019). HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice. Cancer Cell, 36(6), 645-659.e8. https://doi.org/10.1016/j.ccell.2019.10.011