HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

Huacheng Luo, Ganqian Zhu, Jianfeng Xu, Qian Lai, Bowen Yan, Ying Guo, Tsz Kan Fung, Bernd B. Zeisig, Ya Cui, Jie Zha, Christopher Cogle, Fei Wang, Bing Xu, Feng Chun Yang, Wei Li, Chi Wai Eric So, Yi Qiu, Mingjiang Xu, Suming Huang

Research output: Contribution to journalArticle

Abstract

Luo et al. find that the lncRNA HOTTIP is overexpressed in acute myeloid leukemia (AML). They show that HOTTIP coordinates topologically associated domain organization in the AML genome, including the posterior HOXA genes and various key hematopoietic regulator loci, and is important for AML growth.

Original languageEnglish (US)
Pages (from-to)645-659.e8
JournalCancer Cell
Volume36
Issue number6
DOIs
StatePublished - Dec 9 2019

Fingerprint

Long Noncoding RNA
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Genome
Growth
Genes
Cell Self Renewal

Keywords

  • chromatin domain
  • CTCF boundary
  • enhancer/promoter accessibility
  • HOTTIP lncRNA
  • HOTTIP transgenic mice
  • HOX and hematopoietic gene regulation
  • HSC self-renewal
  • leukemia
  • WNT signaling targets

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice. / Luo, Huacheng; Zhu, Ganqian; Xu, Jianfeng; Lai, Qian; Yan, Bowen; Guo, Ying; Fung, Tsz Kan; Zeisig, Bernd B.; Cui, Ya; Zha, Jie; Cogle, Christopher; Wang, Fei; Xu, Bing; Yang, Feng Chun; Li, Wei; So, Chi Wai Eric; Qiu, Yi; Xu, Mingjiang; Huang, Suming.

In: Cancer Cell, Vol. 36, No. 6, 09.12.2019, p. 645-659.e8.

Research output: Contribution to journalArticle

Luo, H, Zhu, G, Xu, J, Lai, Q, Yan, B, Guo, Y, Fung, TK, Zeisig, BB, Cui, Y, Zha, J, Cogle, C, Wang, F, Xu, B, Yang, FC, Li, W, So, CWE, Qiu, Y, Xu, M & Huang, S 2019, 'HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice', Cancer Cell, vol. 36, no. 6, pp. 645-659.e8. https://doi.org/10.1016/j.ccell.2019.10.011
Luo, Huacheng ; Zhu, Ganqian ; Xu, Jianfeng ; Lai, Qian ; Yan, Bowen ; Guo, Ying ; Fung, Tsz Kan ; Zeisig, Bernd B. ; Cui, Ya ; Zha, Jie ; Cogle, Christopher ; Wang, Fei ; Xu, Bing ; Yang, Feng Chun ; Li, Wei ; So, Chi Wai Eric ; Qiu, Yi ; Xu, Mingjiang ; Huang, Suming. / HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice. In: Cancer Cell. 2019 ; Vol. 36, No. 6. pp. 645-659.e8.
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AU - Luo, Huacheng

AU - Zhu, Ganqian

AU - Xu, Jianfeng

AU - Lai, Qian

AU - Yan, Bowen

AU - Guo, Ying

AU - Fung, Tsz Kan

AU - Zeisig, Bernd B.

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AU - Zha, Jie

AU - Cogle, Christopher

AU - Wang, Fei

AU - Xu, Bing

AU - Yang, Feng Chun

AU - Li, Wei

AU - So, Chi Wai Eric

AU - Qiu, Yi

AU - Xu, Mingjiang

AU - Huang, Suming

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