TY - JOUR
T1 - Hot topics in pharmacogenetics of age-related macular degeneration
AU - Schwartz, Stephen G.
AU - Brantley, Milam A.
AU - Kovach, Jaclyn L.
AU - Grzybowski, Andrzej
N1 - Funding Information:
Partially supported by NIH Center Core Grant P30EY014801 and by an unrestricted grant from Research to Prevent Blindness, New York, NY.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Age-related macular degeneration (AMD) is a leading cause of irreversible visual loss and is primarily treated with nutritional supplementation as well as with anti-vascular endothelial growth factor (VEGF) agents for certain patients with neovascular disease. AMD is a complex disease with both genetic and environmental risk factors. In addition, treatment outcomes from nutritional supplementation and anti-VEGF agents vary considerably. Therefore, it is reasonable to suspect that there may be pharmacogenetic influences on these treatments. Many series have reported individual associations with variants in complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), and other loci. However, at this time there are no validated associations. With respect to AMD, pharmacogenetics remains an intriguing area of research but is not helpful for routine clinical management.
AB - Age-related macular degeneration (AMD) is a leading cause of irreversible visual loss and is primarily treated with nutritional supplementation as well as with anti-vascular endothelial growth factor (VEGF) agents for certain patients with neovascular disease. AMD is a complex disease with both genetic and environmental risk factors. In addition, treatment outcomes from nutritional supplementation and anti-VEGF agents vary considerably. Therefore, it is reasonable to suspect that there may be pharmacogenetic influences on these treatments. Many series have reported individual associations with variants in complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), and other loci. However, at this time there are no validated associations. With respect to AMD, pharmacogenetics remains an intriguing area of research but is not helpful for routine clinical management.
KW - Age-related eye disease study (AREDS)
KW - Age-related macular degeneration (AMD)
KW - Age-related maculopathy susceptibility 2 (ARMS2)
KW - Complement factor H (CFH)
KW - Pharmacogenetics
KW - Vascular endothelial growth factor (VEGF)
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U2 - 10.2174/1381612822666161208114847
DO - 10.2174/1381612822666161208114847
M3 - Article
C2 - 27928964
AN - SCOPUS:85018490770
VL - 23
SP - 547
EP - 550
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 4
ER -