Hot topics in perioperative antibiotics for cataract surgery

Patrycja Kuklo, Andrzej Grzybowski, Stephen Schwartz, Harry W Flynn, Avinash Pathengay

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Acute-onset postoperative endophthalmitis is an uncommon but potentially serious complication of cataract surgery. Since there are relatively few randomized clinical trials comparing the timing and administration of prophylactic antibiotics, there are wide variations in prevention practices around the world. Methods: Literature review. Results: Antibiotics may be used before surgery, during surgery, or after surgery in an attempt to decrease the rates of endophthalmitis. Antibiotics may be delivered by various routes, including topical, subconjunctival, in the irrigating solution, or by bolus intracameral injection. Polymerase chain reaction and other DNA identification techniques for bacterial isolates and their antibiotic sensitivity profiles will play an important role in future management strategies. Conclusion: There is no consensus regarding the precise use of antibiotics in the perioperative period. Because of increased multidrug-resistant bacteria, evolving strategies are needed to address these issues.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalCurrent Pharmaceutical Design
Volume23
Issue number4
DOIs
StatePublished - Feb 1 2017

Fingerprint

Cataract
Anti-Bacterial Agents
Endophthalmitis
Perioperative Period
Randomized Controlled Trials
Bacteria
Polymerase Chain Reaction
Injections
DNA

Keywords

  • Cefuroxime
  • Endophthalmitis
  • Endophthalmitis Vitrectomy Study (EVS)
  • Intracameral antibiotics
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Hot topics in perioperative antibiotics for cataract surgery. / Kuklo, Patrycja; Grzybowski, Andrzej; Schwartz, Stephen; Flynn, Harry W; Pathengay, Avinash.

In: Current Pharmaceutical Design, Vol. 23, No. 4, 01.02.2017, p. 551-557.

Research output: Contribution to journalArticle

Kuklo, Patrycja ; Grzybowski, Andrzej ; Schwartz, Stephen ; Flynn, Harry W ; Pathengay, Avinash. / Hot topics in perioperative antibiotics for cataract surgery. In: Current Pharmaceutical Design. 2017 ; Vol. 23, No. 4. pp. 551-557.
@article{fb261768aff24c6ba54456f78de75b8f,
title = "Hot topics in perioperative antibiotics for cataract surgery",
abstract = "Background: Acute-onset postoperative endophthalmitis is an uncommon but potentially serious complication of cataract surgery. Since there are relatively few randomized clinical trials comparing the timing and administration of prophylactic antibiotics, there are wide variations in prevention practices around the world. Methods: Literature review. Results: Antibiotics may be used before surgery, during surgery, or after surgery in an attempt to decrease the rates of endophthalmitis. Antibiotics may be delivered by various routes, including topical, subconjunctival, in the irrigating solution, or by bolus intracameral injection. Polymerase chain reaction and other DNA identification techniques for bacterial isolates and their antibiotic sensitivity profiles will play an important role in future management strategies. Conclusion: There is no consensus regarding the precise use of antibiotics in the perioperative period. Because of increased multidrug-resistant bacteria, evolving strategies are needed to address these issues.",
keywords = "Cefuroxime, Endophthalmitis, Endophthalmitis Vitrectomy Study (EVS), Intracameral antibiotics, Polymerase chain reaction",
author = "Patrycja Kuklo and Andrzej Grzybowski and Stephen Schwartz and Flynn, {Harry W} and Avinash Pathengay",
year = "2017",
month = "2",
day = "1",
doi = "10.2174/1381612822666161208095348",
language = "English (US)",
volume = "23",
pages = "551--557",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Hot topics in perioperative antibiotics for cataract surgery

AU - Kuklo, Patrycja

AU - Grzybowski, Andrzej

AU - Schwartz, Stephen

AU - Flynn, Harry W

AU - Pathengay, Avinash

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Background: Acute-onset postoperative endophthalmitis is an uncommon but potentially serious complication of cataract surgery. Since there are relatively few randomized clinical trials comparing the timing and administration of prophylactic antibiotics, there are wide variations in prevention practices around the world. Methods: Literature review. Results: Antibiotics may be used before surgery, during surgery, or after surgery in an attempt to decrease the rates of endophthalmitis. Antibiotics may be delivered by various routes, including topical, subconjunctival, in the irrigating solution, or by bolus intracameral injection. Polymerase chain reaction and other DNA identification techniques for bacterial isolates and their antibiotic sensitivity profiles will play an important role in future management strategies. Conclusion: There is no consensus regarding the precise use of antibiotics in the perioperative period. Because of increased multidrug-resistant bacteria, evolving strategies are needed to address these issues.

AB - Background: Acute-onset postoperative endophthalmitis is an uncommon but potentially serious complication of cataract surgery. Since there are relatively few randomized clinical trials comparing the timing and administration of prophylactic antibiotics, there are wide variations in prevention practices around the world. Methods: Literature review. Results: Antibiotics may be used before surgery, during surgery, or after surgery in an attempt to decrease the rates of endophthalmitis. Antibiotics may be delivered by various routes, including topical, subconjunctival, in the irrigating solution, or by bolus intracameral injection. Polymerase chain reaction and other DNA identification techniques for bacterial isolates and their antibiotic sensitivity profiles will play an important role in future management strategies. Conclusion: There is no consensus regarding the precise use of antibiotics in the perioperative period. Because of increased multidrug-resistant bacteria, evolving strategies are needed to address these issues.

KW - Cefuroxime

KW - Endophthalmitis

KW - Endophthalmitis Vitrectomy Study (EVS)

KW - Intracameral antibiotics

KW - Polymerase chain reaction

UR - http://www.scopus.com/inward/record.url?scp=85018503613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018503613&partnerID=8YFLogxK

U2 - 10.2174/1381612822666161208095348

DO - 10.2174/1381612822666161208095348

M3 - Article

VL - 23

SP - 551

EP - 557

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 4

ER -