Hot topics in perioperative antibiotics for cataract surgery

Patrycja Kuklo, Andrzej Grzybowski, Stephen G. Schwartz, Harry W. Flynn, Avinash Pathengay

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Acute-onset postoperative endophthalmitis is an uncommon but potentially serious complication of cataract surgery. Since there are relatively few randomized clinical trials comparing the timing and administration of prophylactic antibiotics, there are wide variations in prevention practices around the world. Methods: Literature review. Results: Antibiotics may be used before surgery, during surgery, or after surgery in an attempt to decrease the rates of endophthalmitis. Antibiotics may be delivered by various routes, including topical, subconjunctival, in the irrigating solution, or by bolus intracameral injection. Polymerase chain reaction and other DNA identification techniques for bacterial isolates and their antibiotic sensitivity profiles will play an important role in future management strategies. Conclusion: There is no consensus regarding the precise use of antibiotics in the perioperative period. Because of increased multidrug-resistant bacteria, evolving strategies are needed to address these issues.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalCurrent pharmaceutical design
Volume23
Issue number4
DOIs
StatePublished - Feb 1 2017

Keywords

  • Cefuroxime
  • Endophthalmitis
  • Endophthalmitis Vitrectomy Study (EVS)
  • Intracameral antibiotics
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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