Host defense, viruses and apoptosis

Research output: Contribution to journalArticle

356 Citations (Scopus)

Abstract

To thwart viral infection, the host has developed a formidable and integrated defense network that comprises our innate and adaptive immune response. In recent years, it has become clear that in an attempt to prevent viral replication, viral dissemination or persistent viral infection of the cell, many of these protective measures actually involve the induction of programmed cell death, or apoptosis. An initial response to viral infection primarily involves the innate arm of immunity and the killing of infected cells with cytotoxic lymphocytes such as natural killer (NK) cells through mechanisms that include the employment of perforin and granzymes. Once the virus has invaded the cell, however, a second host defense-mediated response is also triggered which involves the induction of a family of cytokines known as the interferons (IFNs). The IFNs, which are essential for initiating and coordinating a successful antiviral response, function by stimulating the adaptive arm of immunity involving cytotoxic T cells (CTLs), and by inducing a number of intracellular genes that directly prevent virus replication/cytolysis or that facilitate apoptosis. The IFN-induced gene family is now known to comprise the death ligand TRAIL, the dsRNA-dependent protein kinase (PKR), interferon regulatory factors (IRFs) and the promyelocytic leukemia gene (PML), all of which have been reported to be mediators of cell death. That DNA array analyses indicate that numerous cellular genes, many as yet uncharacterized, may similarly be induced by IFN, further emphasizes the likely importance that these cytokines have in the modulation of apoptosis. This likelihood is additionally underlined by the elaborate strategies developed by viruses to inhibit IFN-antiviral function and the mechanisms of cell death.

Original languageEnglish
Pages (from-to)113-126
Number of pages14
JournalCell Death and Differentiation
Volume8
Issue number2
DOIs
StatePublished - Mar 20 2001

Fingerprint

Interferons
Apoptosis
Viruses
Virus Diseases
Cell Death
Adaptive Immunity
Innate Immunity
Genes
Antiviral Agents
Interferon Regulatory Factors
eIF-2 Kinase
Cytokines
Granzymes
Perforin
Virus Replication
Oligonucleotide Array Sequence Analysis
Natural Killer Cells
Leukemia
Lymphocytes
Ligands

Keywords

  • Apoptosis
  • Immunity
  • Virus

ASJC Scopus subject areas

  • Cell Biology

Cite this

Host defense, viruses and apoptosis. / Barber, Glen N.

In: Cell Death and Differentiation, Vol. 8, No. 2, 20.03.2001, p. 113-126.

Research output: Contribution to journalArticle

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