Hormones and breast cancer in vitro.

R. B. Dickson, E. W. Thompson, Marc E Lippman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Breast cancer is characterized by hormonal regulation. The current article reviews the role of estrogen and polypeptide growth factors in control of proliferation and basement membrane invasion of breast cancer cells in vitro. The role of antiestrogens to regulate proliferation, invasion, and growth factor secretion is further highlighted. Finally, the use of in vitro cultures of breast cancer cells to model steps in the malignant progression of the disease is emphasized. The availability of hormone dependent and independent breast cancer cell lines should allow screening for better antiestrogens, antimetastatic drugs, and antagonists of local action of growth factors.

Original languageEnglish
Pages (from-to)219-230
Number of pages12
JournalHuman cell : official journal of Human Cell Research Society
Volume2
Issue number3
StatePublished - Sep 1 1989
Externally publishedYes

Fingerprint

Hormones
Breast Neoplasms
Intercellular Signaling Peptides and Proteins
Estrogen Receptor Modulators
Basement Membrane
Disease Progression
Estrogens
Cell Line
Peptides
In Vitro Techniques
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dickson, R. B., Thompson, E. W., & Lippman, M. E. (1989). Hormones and breast cancer in vitro. Human cell : official journal of Human Cell Research Society, 2(3), 219-230.

Hormones and breast cancer in vitro. / Dickson, R. B.; Thompson, E. W.; Lippman, Marc E.

In: Human cell : official journal of Human Cell Research Society, Vol. 2, No. 3, 01.09.1989, p. 219-230.

Research output: Contribution to journalArticle

Dickson, RB, Thompson, EW & Lippman, ME 1989, 'Hormones and breast cancer in vitro.', Human cell : official journal of Human Cell Research Society, vol. 2, no. 3, pp. 219-230.
Dickson RB, Thompson EW, Lippman ME. Hormones and breast cancer in vitro. Human cell : official journal of Human Cell Research Society. 1989 Sep 1;2(3):219-230.
Dickson, R. B. ; Thompson, E. W. ; Lippman, Marc E. / Hormones and breast cancer in vitro. In: Human cell : official journal of Human Cell Research Society. 1989 ; Vol. 2, No. 3. pp. 219-230.
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