Hormones and breast cancer in vitro.

R. B. Dickson, E. W. Thompson, M. E. Lippman

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Breast cancer is characterized by hormonal regulation. The current article reviews the role of estrogen and polypeptide growth factors in control of proliferation and basement membrane invasion of breast cancer cells in vitro. The role of antiestrogens to regulate proliferation, invasion, and growth factor secretion is further highlighted. Finally, the use of in vitro cultures of breast cancer cells to model steps in the malignant progression of the disease is emphasized. The availability of hormone dependent and independent breast cancer cell lines should allow screening for better antiestrogens, antimetastatic drugs, and antagonists of local action of growth factors.

Original languageEnglish (US)
Pages (from-to)219-230
Number of pages12
JournalHuman cell : official journal of Human Cell Research Society
Issue number3
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research


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