Hormone response element binding proteins: Novel regulators of vitamin D and estrogen signaling

Thomas S. Lisse, Martin Hewison, John S. Adams

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Insights from vitamin D-resistant New World primates and their human homologues as models of natural and pathological insensitivity to sterol/steroid action have uncovered a family of novel intracellular vitamin D and estrogen regulatory proteins involved in hormone action. The proteins, known as "vitamin D or estrogen response element-binding proteins", behave as potent cis-acting, transdominant regulators to inhibit steroid receptor binding to DNA response elements and is responsible for vitamin D and estrogen resistances. This set of interactors belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family of previously known pre-mRNA-interacting proteins. This review provides new insights into the mechanism by which these novel regulators of signaling and metabolism can act to regulate responses to vitamin D and estrogen. In addition the review also describes other molecules that are known to influence nuclear receptor signaling through interaction with hormone response elements.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
Issue number4
StatePublished - Mar 2011
Externally publishedYes


  • 1,25-Dihydroxyvitamin D3
  • Estrogen response element binding protein
  • Heterogeneous nuclear ribonucleoprotein
  • Human hereditary vitamin D-resistant rickets
  • Vitamin D receptor
  • Vitamin D response element-binding protein

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry


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