Hormone Receptors in Breast Cancer and Response to Chemotherapy

Christian Sauter, M. Kaufmann, K. Klinga, B. Runnebaum, F. Kubli, Sewa S. Legha, George R. Blumenschien, Aman U. Buzdar, Gabriel N. Hortobagyi, Walter B. Panko, David T. Kiang, B. J. Kennedy, Daniel H. Frenning, Marc E. Lippman, Joseph C. Allegra

Research output: Contribution to journalLetter

10 Scopus citations


To the Editor: The contradictory results presented by Lippman et al.1 and Kiang et al.2 on estrogen receptors and the treatment of breast cancer are not surprising. With the methods used by both groups, the quantity of receptors is expressed per amount of cytosol protein extracted. The number of tumor cells in each sample is, however, unknown. This number certainly varies a great deal; a given weight of medullary carcinoma, for example, may contain 100 times as many tumor cells as a scirrhous carcinoma. A real quantitative estrogen-receptor assay will only be possible and of value for routine clinical use.

Original languageEnglish (US)
Pages (from-to)1052-1054
Number of pages3
JournalNew England Journal of Medicine
Issue number18
StatePublished - May 3 1979


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sauter, C., Kaufmann, M., Klinga, K., Runnebaum, B., Kubli, F., Legha, S. S., Blumenschien, G. R., Buzdar, A. U., Hortobagyi, G. N., Panko, W. B., Kiang, D. T., Kennedy, B. J., Frenning, D. H., Lippman, M. E., & Allegra, J. C. (1979). Hormone Receptors in Breast Cancer and Response to Chemotherapy. New England Journal of Medicine, 300(18), 1052-1054. https://doi.org/10.1056/NEJM197905033001813