Synthetic LH-RH was administered to prepubertal, pubertal, and adult human males as a four-hour iv infusion at a dose of 100 μg/m2 body surface. Plasma levels of LH, FSH, testosterone, androstenedione and cortisol were measured by radioimmunoassays. It was found, in general, that adults released the most LH and the least FSH after LH-RH. Some increase in testosterone but not cortisol levels was observed. The exact interpretation of the data depends upon whether the results are expressed as maximal increment in absolute amounts (mIU/ml), maximal increment in percent, or total amount of released hormone. Regardless of the manner of expression, however, the results support the original observation that children as well as adults release gonadotropins in response to LH-RH.
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