Hormonal response to synthetic lh-releasing hormone (lh-rh) in prepubertal, pubertal, and adult human males

Jose A. Bermudez, Abba J. Kastin, Don S. Schalch, Daniel Lee-Benitez, Enrique Perez-Pasten, David Gonzalez-Barcena, J. Pedro Arzac, Andrew V. Schally

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Synthetic LH-RH was administered to prepubertal, pubertal, and adult human males as a four-hour iv infusion at a dose of 100 μg/m2 body surface. Plasma levels of LH, FSH, testosterone, androstenedione and cortisol were measured by radioimmunoassays. It was found, in general, that adults released the most LH and the least FSH after LH-RH. Some increase in testosterone but not cortisol levels was observed. The exact interpretation of the data depends upon whether the results are expressed as maximal increment in absolute amounts (mIU/ml), maximal increment in percent, or total amount of released hormone. Regardless of the manner of expression, however, the results support the original observation that children as well as adults release gonadotropins in response to LH-RH.

Original languageEnglish (US)
Pages (from-to)477-493
Number of pages17
JournalEndocrine Research
Volume1
Issue number5-6
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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    Bermudez, J. A., Kastin, A. J., Schalch, D. S., Lee-Benitez, D., Perez-Pasten, E., Gonzalez-Barcena, D., Arzac, J. P., & Schally, A. V. (1974). Hormonal response to synthetic lh-releasing hormone (lh-rh) in prepubertal, pubertal, and adult human males. Endocrine Research, 1(5-6), 477-493. https://doi.org/10.3109/07435807409089002