Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters: Effects of adrenalectomy and corticosteroid implants

Thomas Champney, Cheryl M. Craft, Susan M. Webb, R. J. Reiter

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the activities of the enzymes N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were implanted with the appropriate corticosteroid or adrenalectomized two weeks earlier. Melatonin content and NAT activity were increased at 4 hours (during darkness) in adrenalectomized hamsters; conversely, no alterations in melatonin levels were observed in either adrenalectomized or implanted rats. It is suggested that the changes in adrenal function probably have a minor influence on pineal melatonin production.

Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalJournal of Neural Transmission
Volume64
Issue number1
DOIs
StatePublished - Mar 1 1985
Externally publishedYes

Fingerprint

Adrenalectomy
Mesocricetus
Melatonin
Adrenal Cortex Hormones
Acetylserotonin O-Methyltransferase
5-Hydroxytryptophan
Hydroxyindoleacetic Acid
Acetyltransferases
Darkness
Tryptophan
Cricetinae
Serotonin
Enzymes

Keywords

  • corticosterone
  • cortisol adrenalectomy
  • melatonin
  • Pineal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters : Effects of adrenalectomy and corticosteroid implants. / Champney, Thomas; Craft, Cheryl M.; Webb, Susan M.; Reiter, R. J.

In: Journal of Neural Transmission, Vol. 64, No. 1, 01.03.1985, p. 67-79.

Research output: Contribution to journalArticle

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