TY - JOUR
T1 - Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters
T2 - Effects of streptozotocin-induced diabetes and insulin injections
AU - Champney, Thomas H.
AU - Holtorf, Anke P.
AU - Craft, Cheryl M.
AU - Reiter, Russel J.
N1 - Funding Information:
AcknoMIedRmlenr.v-Thsist udywas fundedb y NSF grant PCM 8003341to R.J.R.. the Anatomy graduate fund to
Funding Information:
T.H.C., and NIH grant 930 HD 10202 (Neuroendocrine Core). This study was undertaken to fulfill a portion of the doctoral dissertation completed by T.H.C.
PY - 1986
Y1 - 1986
N2 - 1. 1. Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the enzyme activities of N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were injected with insulin twice daily for three days, or injected with streptozotocin to induce diabetes. 2. 2. Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats. 3. 3. In hamsters, diabetes reduced the nocturnal peak of pineal melatonin content by approximately one half, while insulin injections had no effect on pineal melatonin levels; however, insulin injections did cause a slight increase in pineal N-acetyltransferase activity. 4. 4. These findings indicate that the pineal gland of the hamster may be more sensitive to alterations in plasma insulin levels than the same organ in rats.
AB - 1. 1. Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the enzyme activities of N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were injected with insulin twice daily for three days, or injected with streptozotocin to induce diabetes. 2. 2. Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats. 3. 3. In hamsters, diabetes reduced the nocturnal peak of pineal melatonin content by approximately one half, while insulin injections had no effect on pineal melatonin levels; however, insulin injections did cause a slight increase in pineal N-acetyltransferase activity. 4. 4. These findings indicate that the pineal gland of the hamster may be more sensitive to alterations in plasma insulin levels than the same organ in rats.
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U2 - 10.1016/0300-9629(86)90594-3
DO - 10.1016/0300-9629(86)90594-3
M3 - Article
C2 - 2420523
AN - SCOPUS:0022646605
VL - 83
SP - 391
EP - 395
JO - Comparative Biochemistry and Physiology -- Part A: Physiology
JF - Comparative Biochemistry and Physiology -- Part A: Physiology
SN - 0300-9629
IS - 2
ER -