Abstract
1. 1. Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the enzyme activities of N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were injected with insulin twice daily for three days, or injected with streptozotocin to induce diabetes. 2. 2. Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats. 3. 3. In hamsters, diabetes reduced the nocturnal peak of pineal melatonin content by approximately one half, while insulin injections had no effect on pineal melatonin levels; however, insulin injections did cause a slight increase in pineal N-acetyltransferase activity. 4. 4. These findings indicate that the pineal gland of the hamster may be more sensitive to alterations in plasma insulin levels than the same organ in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 391-395 |
| Number of pages | 5 |
| Journal | Comparative Biochemistry and Physiology -- Part A: Physiology |
| Volume | 83 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Biochemistry
Cite this
Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters : Effects of streptozotocin-induced diabetes and insulin injections. / Champney, Thomas; Holtorf, Anke P.; Craft, Cheryl M.; Reiter, Russel J.
In: Comparative Biochemistry and Physiology -- Part A: Physiology, Vol. 83, No. 2, 01.01.1986, p. 391-395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hormonal modulation of pineal melatonin synthesis in rats and syrian hamsters
T2 - Effects of streptozotocin-induced diabetes and insulin injections
AU - Champney, Thomas
AU - Holtorf, Anke P.
AU - Craft, Cheryl M.
AU - Reiter, Russel J.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - 1. 1. Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the enzyme activities of N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were injected with insulin twice daily for three days, or injected with streptozotocin to induce diabetes. 2. 2. Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats. 3. 3. In hamsters, diabetes reduced the nocturnal peak of pineal melatonin content by approximately one half, while insulin injections had no effect on pineal melatonin levels; however, insulin injections did cause a slight increase in pineal N-acetyltransferase activity. 4. 4. These findings indicate that the pineal gland of the hamster may be more sensitive to alterations in plasma insulin levels than the same organ in rats.
AB - 1. 1. Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the enzyme activities of N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were injected with insulin twice daily for three days, or injected with streptozotocin to induce diabetes. 2. 2. Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats. 3. 3. In hamsters, diabetes reduced the nocturnal peak of pineal melatonin content by approximately one half, while insulin injections had no effect on pineal melatonin levels; however, insulin injections did cause a slight increase in pineal N-acetyltransferase activity. 4. 4. These findings indicate that the pineal gland of the hamster may be more sensitive to alterations in plasma insulin levels than the same organ in rats.
UR - http://www.scopus.com/inward/record.url?scp=0022646605&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022646605&partnerID=8YFLogxK
U2 - 10.1016/0300-9629(86)90594-3
DO - 10.1016/0300-9629(86)90594-3
M3 - Article
VL - 83
SP - 391
EP - 395
JO - Comparative Biochemistry & Physiology; A: Comparative Physiology
JF - Comparative Biochemistry & Physiology; A: Comparative Physiology
SN - 1095-6433
IS - 2
ER -