Hormonal enhancement of technetium-99m pertechnetate uptake in experimental Meckel's diverticulum

Glen F. Anderson, George Sfakianakis, Denis R. King, E. Thomas Boles

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

A canine model simulating Meckel's diverticulum was used to evaluate the effects of pentagastrin, glucagon, and a combination of the two hormones on the gastrointestinal localization of 99mTc. Pentagastrin produced accelerated uptake of the radionuclide in both the stomach and the ectopic gastric mucosa but resulted in early visualization of the duodenum and a "washout" effect on the radioisotope within the Meckel's diverticulum. Glucagon provided prolonged retention of the radionuclide in the stomach and ectopic mucosa and prevented duodenal visualization. A combination of both hormones produced increased activity in the stomach and experimental Meckel's and decreased duodenal filling. This enhanced target to background contrast and provided improved visualization fo the ectopic gastric mucosa.

Original languageEnglish (US)
Pages (from-to)900-905
Number of pages6
JournalJournal of Pediatric Surgery
Volume15
Issue number6
DOIs
StatePublished - Dec 1980

    Fingerprint

Keywords

  • Tc pertechnetate
  • glucagon
  • Meckel's diverticulum
  • pentagastrin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this