Hormonal enhancement of technetium-99m pertechnetate uptake in experimental Meckel's diverticulum

Glen F. Anderson, George N Sfakianakis, Denis R. King, E. Thomas Boles

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A canine model simulating Meckel's diverticulum was used to evaluate the effects of pentagastrin, glucagon, and a combination of the two hormones on the gastrointestinal localization of 99mTc. Pentagastrin produced accelerated uptake of the radionuclide in both the stomach and the ectopic gastric mucosa but resulted in early visualization of the duodenum and a "washout" effect on the radioisotope within the Meckel's diverticulum. Glucagon provided prolonged retention of the radionuclide in the stomach and ectopic mucosa and prevented duodenal visualization. A combination of both hormones produced increased activity in the stomach and experimental Meckel's and decreased duodenal filling. This enhanced target to background contrast and provided improved visualization fo the ectopic gastric mucosa.

Original languageEnglish
Pages (from-to)900-905
Number of pages6
JournalJournal of Pediatric Surgery
Volume15
Issue number6
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Meckel Diverticulum
Sodium Pertechnetate Tc 99m
Technetium
Radioisotopes
Pentagastrin
Stomach
Gastric Mucosa
Glucagon
Gastrointestinal Hormones
Duodenum
Canidae
Mucous Membrane
Hormones

Keywords

  • Tc pertechnetate
  • glucagon
  • Meckel's diverticulum
  • pentagastrin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Hormonal enhancement of technetium-99m pertechnetate uptake in experimental Meckel's diverticulum. / Anderson, Glen F.; Sfakianakis, George N; King, Denis R.; Thomas Boles, E.

In: Journal of Pediatric Surgery, Vol. 15, No. 6, 01.01.1980, p. 900-905.

Research output: Contribution to journalArticle

Anderson, Glen F. ; Sfakianakis, George N ; King, Denis R. ; Thomas Boles, E. / Hormonal enhancement of technetium-99m pertechnetate uptake in experimental Meckel's diverticulum. In: Journal of Pediatric Surgery. 1980 ; Vol. 15, No. 6. pp. 900-905.
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