@article{f9d231cd352445e0ba849732ec807b53,
title = "Hope vs hype: where are we in type 1 diabetes?",
abstract = "Much progress has been made in type 1 diabetes research. Biological replacement of islet function has been achieved with pancreas transplantation and with islet transplantation. In the future, human embryonic stem cells and/or induced pluripotent stem cells may offer a potentially unlimited source of cells for islet replacement. Another potential strategy is to induce robust beta cell replication so that regeneration of islets can be achieved. Immune interventions are being studied with the hope of arresting the type 1 diabetes disease process to either prevent the disease or help preserve beta cell function. Mechanical replacement of islet cell function involves the use of glucose sensor-controlled insulin infusion systems. As all of these avenues are pursued, headlines often overstate the case, thus hyping any given advance, which provides enormous hope for patients and families seeking a cure for type 1 diabetes. Often, however, it is an animal study or a pilot trial that is being described. The reality is that translation to successful trials in human beings may not be readily achievable. This article discusses both the hype and the hopes in type 1 diabetes research.",
keywords = "Automated insulin delivery, Immune intervention, Islet regeneration, Islet replacement therapy, Review, Stem cells, Type 1 diabetes",
author = "Skyler, {Jay S.}",
note = "Funding Information: Duality of interest The author has acted as an advisor to: Adocia, Abvance, AstraZeneca, BD Technologies, Boehringer Ingelheim, Dance Biopharm, Diavacs, Elcelyx Therapeutics, Eli Lilly and Company, Ideal Life, Immunomolecular Therapeutics, Intrexon, Merck, Orgenesis, Sanofi, Servier, Tolerion, vTv Therapeutics, Valeritas LLC and Viacyte. He has had research funding from: NIH, JDRF, Mesoblast and Viacyte. He is a member of the board of directors of: Dexcom Inc., Intarcia Therapeutics and Moerae Matrix. He has equity in: Dance BioPharma, Dexcom Inc., Ideal Life, Intarcia Therapeutics, Intexon, Moerae Matrix and VasoPrep Surgical. Funding Information: Funding The author is supported by the Diabetes Research Institute Foundation. Funding Information: The author has acted as an advisor to: Adocia, Abvance, AstraZeneca, BD Technologies, Boehringer Ingelheim, Dance Biopharm, Diavacs, Elcelyx Therapeutics, Eli Lilly and Company, Ideal Life, Immunomolecular Therapeutics, Intrexon, Merck, Orgenesis, Sanofi, Servier, Tolerion, vTv Therapeutics, Valeritas LLC and Viacyte. He has had research funding from: NIH, JDRF, Mesoblast and Viacyte. He is a member of the board of directors of: Dexcom Inc., Intarcia Therapeutics and Moerae Matrix. He has equity in: Dance BioPharma, Dexcom Inc., Ideal Life, Intarcia Therapeutics, Intexon, Moerae Matrix and VasoPrep Surgical. Publisher Copyright: {\textcopyright} 2017, Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2018",
month = mar,
day = "1",
doi = "10.1007/s00125-017-4530-x",
language = "English (US)",
volume = "61",
pages = "509--516",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Verlag",
number = "3",
}